Schedule: Charting New Horizons for Discovery & Translational Science

February 10, 2025

Session	Speakers
8:45 AM	GATHER + BREAKFAST
9:15 AM	Welcome
	Mary Klotman, MD   Professor of Medicine; EVP Health Affairs, Duke University; Dean, School of Medicine; Chief Academic Officer, Duke Health Introduction Colin Duckett, PhD Professor of Pathology; Executive Vice Dean for Basic Science About the symposium
9:35 AM	Session 1:  NEXT GENERATION THERAPEUTICS
	Rohit Singh, PhD Assistant Professor of Biostatistics and Bioinformatics Introduction Rohit Singh, PhD Assistant Professor of Biostatistics and Bioinformatics From Project Gutenberg to Gene Therapy Emma Chory, PhD Assistant Professor of Biomedical Engineering Navigating the Evolution Multiverse: A Real-Time Platform for Tracking Evolution Outcomes Mihai Azoitei, PhD Associate Professor of Cell Biology Rational Protein Design for Broadly Protective Vaccines Lee Zou, PhD Professor and Chair of Pharmacology and Cancer Biology New Therapeutic Targets in Cancer Therapy
11:00 AM	COFFEE BREAK + SNACKS
11:10 AM	Session 2:    MODELING BIOLOGY: MOLECULES TO POPULATIONS
	Scott Soderling, PhD Professor and Chair of Cell Biology Introduction Pranam Chatterjee, PhD Assistant Professor of Biomedical Engineering Programmable Protein Therapeutics via Generative Language Models Amy Gladfelter, PhD Professor of Cell Biology A Physical Code in RNA Lingchong You, PhD Professor of Biomedical Engineering Predicting Microbiome Dynamics Jessilyn Dunn, PhD Assistant Professor of Biomedical Engineering The Digital Physiome: Wearables for Disease Detection and Monitoring
12:35 PM	LUNCH & POSTERS
1:35 PM	Session 3:  DECODING & MODULATING THE BRAIN
	Steve Lisberger, PhD Professor and Chair of Neurobiology Introduction Nanthia Suthana, PhD Instructor of Neurosurgery Decoding and Modulating Memory with Responsive Deep Brain Stimulation Nuo Li, PhD Associate Professor of Neurobiology Tracking the Formation of Long-Term Motor Memory in the Brain Derek Southwell, MD, PhD Assistant Professor of Neurosurgery Dissecting and Restoring Cortical Inhibitory Circuits in the Human Brain Chantell Evans, PhD Assistant Professor of Cell Biology Investigating Mitochondrial Dysregulation in Neurodegenerative Disease
3:00 PM	COFFEE BREAK + SNACKS
3:10 PM	Session 4:  IMMUNOENGINEERING TO REBALANCE INFLAMMATION & REGENERATION
	Colin Duckett, PhD Professor of Pathology; Executive Vice Dean for Basic Science Introduction Purushothama Rao Tata, PhD Associate Professor of Cell Biology Setting the Stage: Insights and Practical Strategies for Modulating Inflammation to Enhance Tissue Regeneration Bart Haynes, MD Professor of Medicine; Director of the Human Vaccine Institute Engineering the B Cell Arm of the Immune System to Prevent and Treat Disease Carolyn Coyne, PhD Professor of Integrative Immunobiology Inflammation at the Crossroads of Maternal and Fetal Health During Pregnancy Julia Oh, PhD Instructor of Dermatology The Human Microbiome: From Metagenomes to Therapeutics
4:35 PM	Closing remarks for Day 1
	Colin Duckett, PhD Professor of Pathology; Executive Vice Dean for Basic Science

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February 11, 2025

Session	Speakers
8:45 AM	Gather + Breakfast
9:15 AM	Welcome to day 2
	Colin Duckett, PhD Professor of Pathology; Executive Vice Dean for Basic Science
9:25 AM	Session 5: TRANSLATIONAL SCIENCE ACCELERATOR:BRIDGING DISCOVERY & CLINICAL IMPACT
	Colin Duckett, PhD Professor of Pathology; Executive Vice Dean for Basic Science Introduction Susanna Naggie, MD Professor of Medicine; Vice Dean for Clinical Research Crossing the Valley: Strategies for Successful Translation of Research to Practice Rishi Kamaleswaran, PhD Associate Professor of Surgery Every Breath, Every Beat: Integrating Multi-Modal Real Time Data Streams to Inform Personalized Medicine in Acute and Critical Care Donald McDonnell, PhD Professor of Pharmacology and Cancer Biology Drug Repurposing as a Quick Path to Translation Zhao Zhang, PhD Associate Professor of Pharmacology and Cancer Biology Finding a Cure for Cancer in Junk DNA? Jose Conejo-Garcia, MD, PhD Professor of Integrative Immunobiology Biology-Guided Development of “Off-the-Shelf” CAR g/d T Cells Against Solid Tumors
10:55 AM	Symposium Closing Remarks
	Colin Duckett, PhD Professor of Pathology; Executive Vice Dean for Basic Science
11:30 AM	Lunch
12:00 PM	The 2025 Robert J. Lefkowitz, MD, Distinguished Lecture
	Carl H. June, MD The Long and Winding Road Traveled by CAR T Cells

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Poster Session

Monday, February 10 - 12:35 PM

Ordered alphabetically by presenter’s last name

Presenters’ names are in bold font

 

A Gene Regulatory Element Modulates Myosin Expression and Alters Cellular Response to Stress

Taylor Anglen^1,2, Irene M. Kaplow^2,3, Baekgyu Choi⁴, Enya Dewars¹, Robin M. Perelli¹, Kevin T. Hagy^2,3, Duc Tran^1,2, Megan E. Ramaker⁵, Svati Shah^5,6, Inkyung Jung⁴, Andrew P. Landstrom^1,7, Ravi Karra^{6, 8-9}, Yarui Diao^1,2, Charles A. Gersbach^2,3*

¹Cell Biology, Duke University School of Medicine

²Center for Advanced Genomic Technologies, Duke University

³Biomedical Engineering, Duke University

⁴Department of Biological Science, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

⁵Duke Molecular Physiology Institute, Duke University School of Medicine

⁶Division of Cardiology, Department of Medicine, Duke University School of Medicine

⁷Department of Pediatrics, Division of Cardiology, Duke University School of Medicine

⁸Department of Medicine, Duke University School of Medicine

⁹Department of Pathology, Duke University School of Medicine

Human Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury  

Sadhna O. Piryani, Elizabeth Fan, Angel Y. Kam, Yiqun Jiao, Nelson J. Chao, Phuong L. Doan, Benny J. Chen

Division of Hematologic Malignancies and Cellular Therapy, Duke University School of Medicine

Insula Functional Connectivity During Retrieval and Reappraisal of Negative Memories in Transdiagnostic Emotion Dysregulation

Nimesha Gerlus^1,2, Alisa C. Schutz², Andrada D. Neacsiu³, John L. Graner², Moria J. Smoski^2,3, Kevin S. LaBar^2,3

¹Medical Scientist Training Program, Duke University School of Medicine

²Department of Psychology and Neuroscience, Duke University School of Medicine

³Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine

Synergizing Hyperthermia and Immunotherapy in Intracranial Tumors          

Aden P. Haskell-Mendoza, Lucas P. Wachsmuth, Richard Tyc, Shannon Wallace, Peter E. Fecci

Polycomb Repressive Complex 2 Regulates Olfactory Basal Cell Fate During Adult Olfactory Neurogenesis

Tiffany Ko¹, Rhea Choi², and Bradley J. Goldstein²

¹Department of Neurobiology, Duke University School of Medicine

²Department of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine

Longitudinal Monitoring of Childhood Glaucoma Using Virtual Reality Visual Field Testing

Zara Saleem¹, Aya Farag¹, Bo Wang², Rizul Naithani¹, Mays El-Dairi¹, Sharon F. Freedman¹

¹Department of Ophthalmology, Duke University School of Medicine

²Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins Medicine, Baltimore, MD

A Semi-Automated SP3 Sample Preparation Method for High Throughput Screening of in vivo BioID Labeling on an Orbitrap Astral

Greg Waitt¹, Jaebin Kim², Lucio Schiapparelli², Scott Soderling², Erik Soderblom^1,2

¹Proteomics and Metabolomics Core Facility, Duke University School of Medicine
²Department of Cell Biology, Duke University School of Medicine

Computational Design of Guanine Exchange Factors Inhibitors to Modulate BCR Signaling

Fabiola Vacca^1,2, Daniel Marston^1,2, Irina Dumbravanu^1,2, Brianna Rhodes^1,2, Daniel Wrapp², Mihai Azoitei^1,2

¹Department of Cell Biology, Duke University School of Medicine

²Duke Human Vaccine Institute, Duke University School of Medicine

Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM Phosphorylation

Shiyi Wang¹, Ryan Baumert¹, Gabrielle Séjourné¹, Dhanesh Sivadasan Bindu¹, Leslie Vazquez¹, Kristina Sakers^1,9, Jessica Moore^1,9, Christabel Xin Tan¹, Tetsuya Takano^2,3, Kylie Dimond^1,9, Maria Pia Rodriguez¹, Scott H. Soderling^1,4,5, Albert R. La Spada^6,7,8, and Cagla Eroglu^1,4,5,9

¹The Department of Cell Biology, Duke University School of Medicine

²Division of Molecular Systems for Brain Function, Kyushu University Institute for Advanced Study, Medical Institute of Bioregulation, Japan

³Japan Science and Technology Agency, PRESTO, Japan

⁴The Department of Neurobiology, Duke University School of Medicine

⁵Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD

⁶The Department of Neurology, Duke University School of Medicine

⁷Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine, CA, USA

⁸UCI Center for Neurotherapeutics, University of California, Irvine, CA, USA

⁹Howard Hughes Medical Institute, Duke University School of Medicine

Volitional Upregulation of the VTA in ADHD with Real-Time fMRI Neurofeedback

Jia-Hou Poh^1,2, Rachael Wright², Katherine Dickerson², Shabnam Hakimi², Kelly Eom², Benjamin Muzekari², R. Alison Adcock²

¹National University of Singapore

²Department of Psychology & Neuroscience, DIBS, and the Center for Cognitive Neuroscience, Duke University     

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