Research

various researchers

Duke University School of Medicine is the vibrant home for the next generation of discovery. Our capacity for innovation stems from knitting together our existing strengths in fundamental basic science and deepening our growing translational capabilities, our integration with Duke’s national recognized clinical enterprise, and our unique scale and depth in clinical research. The combined efforts of the school’s basic and clinical faculty members in 26 departments, and numerous centers, institutes and initiatives make Duke one of the largest biomedical research enterprises in the country with $1 billlion in sponsored research expenditures annually. 

Research in the News

Zhao Zhang, PhD , associate professor of pharmacology and cancer biology, has been named a recipient of the 2024 Distinguished Scientist Award from The Sontag Foundation.
Mouse study reveals vagus nerve stimulation eases colitis symptoms by regulating inflammation-triggering SUMOylation, a cellular process that shapes immune response.
Research from Duke Science and Technology scholar Nuo Li, PhD, used a novel technique for tracking learning to reveal that the brain’s storage of certain memories is more complex and stable than previously thought.
Spinocerebellar ataxias are a group of neurodegenerative disorders that impact muscle coordination and control. Due to the complexity of the brain, these disorders have been poorly understood. Duke researchers are now using single-cell RNA sequencing technologies to gain a deeper understanding of how these diseases develop, which may lead to better treatment options for patients.
Duke Science and Technology, Challenge Accepted

Duke Science and Technology

Duke University in 2019 initiated a university-wide effort to elevate and sustain excellence in the sciences with new funding for research, recruitment of nationally recognized scholars, and retainment of highly regarded scientific leaders at Duke. Launched with a $100 million investment from The Duke Endowment — divided equally between the university and the School of Medicine — Duke Science and Technology (DST) positions Duke to maximize the potential of revolutionary advances in fields such as genomics, data science, and artificial intelligence.

The effort focuses on three broad thematic pillars: Resilience: Fortifying the Body and Brain, which seeks to harness the body’s intrinsic mechanisms to fight disease; Computing, involving fields such as artificial intelligence and machine learning; and Materials Science, which seeks to engineer new materials to solve challenges in disparate fields.

School of Medicine researchers are leading in efforts to advance the Body and Brain Resilience pillar, focusing on four broad areas where Duke has significant strengths: brain, cancer, immunology, and viruses. Seven DST Scholars have been recruited as faculty in the School of Medicine.

Duke Science and Technology

Nobel Laureates  Robert Lefkowitz, MD and Paul Modrich, Ph.D.

Nobel Laureates

Duke University School of Medicine is proud to claim two Nobel Laureates among its faculty. Robert Lefkowitz, M.D., professor of medicine and a Howard Hughes Medical Institute Investigator, was recognized in 2012 for his work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary diseases. Paul Modrich, Ph.D., professor of biochemistry and a Howard Hughes Medical Institute Investigator, was recognized in 2015 for mapping, at a molecular level, how cells repair damaged DNA and safeguard the genetic information.

 

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