Victor Ayeni, MD, and fellow residents at the Stead Tread 5K

A resident’s mission to serve beyond the clinic fuels community connections

Victor Ayeni, MD, a resident in Duke’s Internal Medicine Residency Program, is bringing fellow residents closer to Durham — one connection at a time. Since arriving in 2024, he has helped residents engage with the community through hands-on service, creative programming, and meaningful partnerships.
Illustration of chemical control of β-arrestins

Study reveals first drug-like molecules that control key cellular signaling proteins

A team at Duke University School of Medicine, led by Nobel laureate Robert Lefkowitz, MD, report the first compounds that directly switch off β-arrestins, which regulate GPCRs — widely used drug targets present throughout the body. Published in Nature, the findings provide the first clear way to control these proteins with pharmacological precision.
Anna Lehmann, a PhD candidate in the Department of Molecular Genetics and Microbiology, looks at a sample of Aspergillus fumigatus.

PhD candidate discovers a hidden way that a fungal pathogen may resist treatment

Some fungal pathogens survive antifungal drugs by mutating. But Aspergillus fumigatus, a common mold, has a stealthier strategy: it duplicates entire chromosomes, rides out the threat, then discards the extra genetic material once the pressure lifts — leaving no trace that resistance ever occurred. Duke University School of Medicine PhD candidate Anna Lehmann made the discovery while working in the lab of Joseph Heitman, MD, PhD, James B. Duke Distinguished Professor and chair of the Department of Molecular Genetics and Microbiology. Her findings, published in the July 2006 issue of Current Biology, establish the first evidence that A. fumigatus can gain and lose entire chromosomes.