The Duke University School of Medicine has a strong tradition of genomic discoveries. The Precision Genomics Collaboratory brings together all of the units in Duke focused on genomics research to create a multi-disciplinary community able to tackle challenges in the ever-evolving genomics landscape.

Featured Publication

Graphical abstract of paper referenced below

APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease

Opeyemi Olabisi, Chris Newgard, Hans-Ewald Hohmeier, Olga Ilkayeva, James Bain, Guofang Zhanag, Paul Rosenberg and colleagues discovered a novel way in which APOL1 G1 induces cell damage. They found that APOL1 G1 (and G2) transport sodium and potassium across the cell membrane, triggering a chain of events leading to cell damage, especially in kidney cells, a key factor in APOL1-mediated kidney disease.

Read full text in the Journal of Clinical Investigations

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Notice of Special Interest (NOSI): Administrative supplements to understand effects of within-group heterogeneity on cancer control outcomes in underrepresented populations

The goal is to support administrative supplements for currently funded investigators to better understand within-group factors that contribute to cancer prevention and control outcomes and intervention effectiveness in populations that are underrepresented in or excluded from cancer research. This administrative supplement would provide funding for one year to initiate or enhance evaluation of heterogeneity within populations and/or how this heterogeneity influences cancer outcomes, within the scope of the parent grant.

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