The Duke University School of Medicine has a strong tradition of genomic discoveries. The Precision Genomics Collaboratory brings together all of the units in Duke focused on genomics research to create a multi-disciplinary community able to tackle challenges in the ever-evolving genomics landscape.
Featured Publication
![Diagrams of predicted regulatory networks of PD GWAS-DEGs](/sites/default/files/images/PD%20%20downregulated.png)
Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks
Ornit Chiba-Falek, Michael Lutz, Allison Ashley-Koch, Greg Crawford and team profiled the transcriptomic and chromatin accessibility landscapes in temporal cortex tissues from 12 Parkinson's disease subjects and compared it to 12 control subjects at a granular single cell resolution. This work provides new insights into a precise glutamatergic neuronal cell subtype, causal genes, and non-coding regulatory variants, paving the way to develop cell- and gene-targeted therapeutics and genetic biomarkers for early preclinical diagnosis.
Funding Opportunity
![Rita Allen Foundation](/sites/default/files/images/rita%20allen%20foundation.png)
Rita Allen Foundation Scholars Award (for Cancer, Immunology and Neuroscience Young Investigators)
The Scholars Program supports research scientists in the early stages of their careers. Fields of research are cancer, immunology and neuroscience. Rita Allen Foundation Scholars are distinguished by their bold approaches to basic scientific questions that address problems of global concern, as well as their potential for learning, leadership and collaboration. Awards are up to $550,000 over 5 years. Deadline: August 4
Our Community
Duke Molecular Physiology Institute
Duke Center for Advanced Genomic Technologies
Duke Center for Genomics and Computational Biology
Duke Center for Statistical Genetics and Genomics
Center for Precision Health
Duke Microbiome Center
Division of Integrative Genomics in the Department of Biostatistics & Bioinformatics
Division of Human Genetics in the Department of Molecular Genetics and Microbiology
Division of Medical Genetics in the Department of Pediatrics
Adult Cardiovascular Genetics Clinic
Clinical Cancer Genetics