Precision Genomics Collaboratory | Duke University School of Medicine

The Duke University School of Medicine has a strong tradition of genomic discoveries. The Precision Genomics Collaboratory brings together all of the units in Duke focused on genomics research to create a multi-disciplinary community able to tackle challenges in the ever-evolving genomics landscape.

Featured Publication

Diagrams of predicted regulatory networks of PD GWAS-DEGs

Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks

Ornit Chiba-Falek, Michael Lutz, Allison Ashley-Koch, Greg Crawford and team profiled the transcriptomic and chromatin accessibility landscapes in temporal cortex tissues from 12 Parkinson's disease subjects and compared it to 12 control subjects at a granular single cell resolution. This work provides new insights into a precise glutamatergic neuronal cell subtype, causal genes, and non-coding regulatory variants, paving the way to develop cell- and gene-targeted therapeutics and genetic biomarkers for early preclinical diagnosis.

Read full text in Acta Neuropathologica Communications

More featured publications

Funding Opportunity

Center for Precision Health & PGC OneDukeGen Pilot Grants

CPH, part of the Duke Clinical & Translational Science Institute (CTSI), and the Duke School of Medicine PGC, are pleased to announce pilot grants with the goal of advancing genomic science at Duke. This request for proposal is open to all Duke SOM faculty and is focused on projects that leverage and enhance the OneDukeGen study infrastructure. Up to 4 grants of up to $40,000 will be awarded.
Deadline: September 9

View full RFP