Precision Genomics Collaboratory | Duke University School of Medicine

The Duke University School of Medicine has a strong tradition of genomic discoveries. The Precision Genomics Collaboratory brings together all of the units in Duke focused on genomics research to create a multi-disciplinary community able to tackle challenges in the ever-evolving genomics landscape.

Featured Publication

Diagrams of predicted regulatory networks of PD GWAS-DEGs

Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks

Ornit Chiba-Falek, Michael Lutz, Allison Ashley-Koch, Greg Crawford and team profiled the transcriptomic and chromatin accessibility landscapes in temporal cortex tissues from 12 Parkinson's disease subjects and compared it to 12 control subjects at a granular single cell resolution. This work provides new insights into a precise glutamatergic neuronal cell subtype, causal genes, and non-coding regulatory variants, paving the way to develop cell- and gene-targeted therapeutics and genetic biomarkers for early preclinical diagnosis.

Read full text in Acta Neuropathologica Communications

More featured publications

Funding Opportunity

Duke Institute for Health Innovation lightbulb icon

Innovation RFA

The Duke Institute for Health Innovation (DIHI) announces the next emerging ideas and innovation funding cycle. Applications are open to faculty, staff, trainees and students of Duke University and Duke University Health System. Proposed innovation projects should address actual and important problems encountered by care providers, patients and their loved one in our clinical enterprise and represent urgent health challenges nationally. Priority will be given to ideas aligned with the thematic area of improving provider and staff experience, patient journey, and clinical outcomes using advanced technology solutions. Funds of up to $60,000 will be awarded

Deadline: October 25

View full RFA