Precision Genomics Collaboratory | Duke University School of Medicine

The Duke University School of Medicine has a strong tradition of genomic discoveries. The Precision Genomics Collaboratory brings together all of the units in Duke focused on genomics research to create a multi-disciplinary community able to tackle challenges in the ever-evolving genomics landscape.

Featured Publication

Diagrams of predicted regulatory networks of PD GWAS-DEGs

Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks

Ornit Chiba-Falek, Michael Lutz, Allison Ashley-Koch, Greg Crawford and team profiled the transcriptomic and chromatin accessibility landscapes in temporal cortex tissues from 12 Parkinson's disease subjects and compared it to 12 control subjects at a granular single cell resolution. This work provides new insights into a precise glutamatergic neuronal cell subtype, causal genes, and non-coding regulatory variants, paving the way to develop cell- and gene-targeted therapeutics and genetic biomarkers for early preclinical diagnosis.

Read full text in Acta Neuropathologica Communications

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Funding Opportunity

Rita Allen Foundation Scholars Award (for Cancer, Immunology and Neuroscience Young Investigators)

The Scholars Program supports research scientists in the early stages of their careers. Fields of research are cancer, immunology and neuroscience. Rita Allen Foundation Scholars are distinguished by their bold approaches to basic scientific questions that address problems of global concern, as well as their potential for learning, leadership and collaboration. Awards are up to $550,000 over 5 years. Deadline: August 4

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