Sequencing and Genomic Technologies (SGT) is a basic science research core affiliated with the Duke Cancer Institute (DCI) that offers a full range of state-of-the-art genomic services. For answers to common questions, please visit our Frequently Asked Questions and Policies.

Director Devi Swain Lenz is available for project consultations.

chip for DNA sequencing

DNA Sequencing
four strands of RNA

RNA Sequencing
tapestri instrument

Single Cell
graphical abstract of bioinformatics

Bioinformatics

News & Announcements

illustration with scientist looking at rna

SGT Core Director to Speak at Duke, QIAGEN webinar

Live Webinar on Monday, May 12:

How to set up your microRNA sequencing project for success

miRNAs are such a big deal that we’ve gathered experts from academia and industry to offer their advice on how to advance your research in the field.

Lunch'n'Learn with Twist Bioscience

Calling all genomics enthusiasts and science trailblazers! Fuel your curiosity (and your appetite!) at the upcoming Twist Bioscience Showcase. The speaker lineup will feature Aileen Ferraro, PhD, from Twist; Amy Goldberg, PhD, David M. Goodner Assistant Professor of Evolutionary Anthropology; and Devi Swain Lenz, PhD, director of the Sequencing and Genomic Technologies core facility and assistant research professor in molecular genetics and microbiology.

Thursday, March 13, 2025
11:30 AM - 1:30 PM
French Science 2237

Transitioning to Watchmaker mRNA Library Prep

We’re excited to transition our mRNA-seq library preparation from KAPA HyperPrep to Watchmaker mRNA Library Prep! Watchmaker provides equivalent data at a cheaper price. If you need to continue using KAPA HyperPrep for continuity, please submit those samples within the next six months

New publication highlights role of human IRGM gene in inflammatory diseases

The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn’s disease. Decreased expression of human IRGM, or the mouse orthologues Irgm1 and Irgm2, leads to increased production of a number of inflammatory chemokines and cytokines in vivo and/or in cultured macrophages. Prior work has indicated that increased cytokine production is instigated by metabolic alterations and changes in mitochondrial homeostasis; however, a comprehensive mechanism has not been elucidated.

Lunch & Learn: Highly accurate HiFi reads for neuroscience research

Many neurological diseases are poorly understood with limited treatment options. Traditional NGS approaches miss important details like structural variants and RNA isoforms, leading to misinterpretations, undiagnosed and untreated neurological conditions. Unravel the complexity of neuroscience by accessing more comprehensive and accurate data with PacBio Revio at the Duke University Sequencing and Genomic Technologies Core Facility.

SGT Closed July 4 & 5

The Sequencing and Genomic Technologies core facility will be not be accepting samples on Thursday, July 4 or Friday, July 5. Business will resume as normal on Monday, July 8.

New LIMS Ordering Website Launches May 6

Sequencing and Genomic Technologies is rolling out our new LIMS ordering website SeqLIMS on May 6, 2024.

New features will simplify ordering, billing, and communications. All new project request should be made on SeqLIMS starting May 6.

Current quotes and orders will continue to be managed on DUGSIM until completion.

Visit SeqLIMS

 

IT Infrastructure Update

The Sequencing and Genomic Technologies is undergoing an update to our IT infrastructure to support the larger datasets produced by the Illumina X Plus and PacBio Revio.

There have been some bugs that have affected data delivery of all sequencers. We are working diligently to resolve the IT issues.
 
There may be delays in data delivery in the next few weeks. We appreciate your understanding and your support of SGT.