The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn’s disease. Decreased expression of human IRGM, or the mouse orthologues Irgm1 and Irgm2, leads to increased production of a number of inflammatory chemokines and cytokines in vivo and/or in cultured macrophages. Prior work has indicated that increased cytokine production is instigated by metabolic alterations and changes in mitochondrial homeostasis; however, a comprehensive mechanism has not been elucidated.

Many neurological diseases are poorly understood with limited treatment options. Traditional NGS approaches miss important details like structural variants and RNA isoforms, leading to misinterpretations, undiagnosed and untreated neurological conditions. Unravel the complexity of neuroscience by accessing more comprehensive and accurate data with PacBio Revio at the Duke University Sequencing and Genomic Technologies Core Facility.

The Sequencing and Genomic Technologies core facility will be not be accepting samples on Thursday, July 4 or Friday, July 5. Business will resume as normal on Monday, July 8.

Sequencing and Genomic Technologies is rolling out our new LIMS ordering website SeqLIMS on May 6, 2024.

New features will simplify ordering, billing, and communications. All new project request should be made on SeqLIMS starting May 6.

Current quotes and orders will continue to be managed on DUGSIM until completion.

Visit SeqLIMS

The Sequencing and Genomic Technologies is undergoing an update to our IT infrastructure to support the larger datasets produced by the Illumina X Plus and PacBio Revio.

There have been some bugs that have affected data delivery of all sequencers. We are working diligently to resolve the IT issues.
 
There may be delays in data delivery in the next few weeks. We appreciate your understanding and your support of SGT.

Introduction to DNA Sequencing
Instructor: Devi Swain Lenz, PhD 
Date and Time: March 20, 1-2 PM 
Location: 2240 CIEMAS

The Sequencing and Genomic Technologies Core Facility has an opening for a Lab Research Analyst.

Sarah Clarke has served as a lab research analyst in the Sequencing and Genomic Technologies (SGT) core facility since 2020. In January, she will be transitioning to a new position at the NC State Vector-Borne Disease Lab. She received her undergraduate degree in natural resource ecology from the University of Vermont in 2020.

How did you arrive at this position at Duke?