Collaborative Research Projects
Duke University and Duke-NUS Medical School (Duke-NUS) announce calls for proposals for collaborative research pilot projects between faculty based in Durham with those based in Singapore. The ultimate goal of this program is the development of international research teams that advance translational and clinical research, including research on medical technologies. Translational research is defined as research with an aim towards human application. Specific areas of focus for Duke-NUS and its Academic Medicine partner, SingHealth, are cancer, neuroscience, cardiometabolic disorders, infectious diseases, inflammation and immunology, eye diseases, health services research, and medical technologies/bioengineering.
2019-2020 Pilot Projects Past Pilot Projects
Duke Faculty: Counter, Christopher, PhD
Professor, Department of Pharmacology & Cancer Biology
Duke Department: Pharmacology & Cancer Biology
Duke-NUS/SingHealth Faculty: Ong, S Tiong, MBBCh
Associate Professor, Cancer & Stem Cell Biology Programme, DNUS
Singapore Program: DNUS - CSCB
Project Title: Elucidating the mechanism by which the splicing factor SRSF1 imparts resistance to tyrosine kinase inhibitors in chronic myeloid leukemia
Duke Faculty: Gersbach, Charles, PhD
Associate Professor, Department of Biomedical Engineering
Duke Department: BME
Duke-NUS/SingHealth Faculty: Rackham, Owen, PhD
Assistant Professor, Centre for Computational Biology; Program in Cardiovascular & Metabolic Disorders ,
Singapore Program: DNUS - CVMD
Project Title: A predictive computational framework for targeted epigenome editing
Duke Faculty: Hirschey, Matthew, PhD
Associate Professor, Departments of Medicine & Pharmacology & Cancer Biology; Duke Molecular Physiology Institute
Duke Department: Medicine – Division of Endocrinology, Metabolism and Nutrition
Duke-NUS/SingHealth Faculty: Han, Weiping, PhD
Deputy Director, Singapore Bioimaging Consortium - A*STAR , DNUS
Singapore Program: DNUS – A*STAR
Project Title: Activation of BCAA metabolism as a therapeutic strategy in cancer
Duke Faculty: Hsu, David Shiao-wen, MD, PhD
William Dalton Family Assistant Professor in Medical Oncology, Department of Medicine
Duke Department: Medicine – Medical Oncology
Duke-NUS/SingHealth Faculty: Madan, Babita, PhD
Assistant Professor, Cancer & Stem Cell Biology Program, DNUS
Singapore Program: DNUS - CSCB
Project Title: Exploiting Wnt Dependencies in Platinum Resistant Cancers
Duke Faculty: Inman, Brant, MD
Vice Chief & Cary N Robertson Associate Professor Urology Department of Surgery; DCI
Duke Department: Surgery – Urology
Duke-NUS/SingHealth Faculty: Rozen, Steven, PhD
Professor of Cancer & Stem Cell Biology; Director, Duke-NUS Center for Computational Biology, DNUS
Singapore Program: DNUS – CSCB
Project Title: Comprehensive genomic profiling to determine the clonal origin and genetic evolution of recurrent urothelial carcinoma
Duke Faculty: Luftig, Micah, PhD
Associate Professor, Department of Molecular Genetics & Microbiology
Duke Department: Molecular Genetics & Microbiology
Duke-NUS/SingHealth Faculty: Tan, Patrick, MD, PhD
Professor, CSCB; Deputy Executive Director, Biomedical Research Council - A*Star; Director PRISM
Singapore Program: DNUS; A*STAR; PRISM; CSCB
Project Title: Development and characterization of preclinical models for EBV- associated gastric cancer
Duke Faculty: Wang, Donghai, PhD
Assistant Professor of Medicine - Rheumatology & Immunology
Duke Department: Medicine Rheumatology & Immunology
Duke-NUS/SingHealth Faculty: Ooi, Eng Eong, BMBS, PhD
FRCPath Professor & Deputy Director, Programme in Emerging infectious Diseases, DNUS
Singapore Program: DNUS – EID
Project Title: Statins Modulate the Efficacy and Safety of Live Attenuated Yellow Fever Virus Vaccine by Inhibiting Protein Geranylgeranylation
Duke Faculty: Wang, Xiao-Fan, PhD
Donald & Elizabeth Cooke Professor of Experimental Oncology, Department of Pharmacology & Cancer Biology
Duke Department: Pharmacology &Cancer Biology
Duke-NUS/SingHealth Faculty: Toh, Hon Chong, MBBCHIR, MRCP, FRCP
Associate Professor of Cancer & Stem Cell Biology Program; Deputy Director & Senior Consultant, NCCS
Singapore Program: DNUS – CSCB; NCCS
Project Title: Systematic T Cell Receptor Repertoire Profiling and Cloning to Improve Therapeutic Outcomes in Advanced EBV-Specific Nasopharyngeal Carcinoma
Duke Faculty: Cheifetz, Ira, MD
Professor of Pediatrics & Anesthesiology - Division of Pediatric Critical Care
Duke Department: Medicine -Rheumatology & Immunology
Duke-NUS/SingHealth Faculty: Lee, Jan Hau, MBBS, MRCPCH
MCI Senior Consultant, Children's Intensive Care Unit; KK Women's & Children's Hospital; Assistant Professor, DNUS
Singapore Program: KKH - Children's, Intensive Care Unit
Project Title: Association Between Nutritional Adequacy, Muscle Wasting and Functional Outcomes in Children Supported on Extracorporeal Membrane Oxygenation: A Dual-Center Cohort Study
Duke Faculty: Habib, Ashraf, MD, FRCA
Professor of Anesthesiology, Department of Anesthesiology - Women's Anesthesiology
Duke Department: Anesthesiology, Women's Anesthesiology
Duke-NUS/SingHealth Faculty: Sng, Ban Leong, MBBS, FAMS
Deputy Head & Senior Consultant, Women's Anesthesia, KKW _
Singapore Program: KKH – Anesthesiology
Project Title: Evaluation and Risk Assessment for Persistent Postsurgical Pain After Breast Surgery: A Collaborative Prospective Cohort Study
Duke Faculty: Knechtle, Stuart J, MD
Professor of Surgery, Executive Director, Duke Transplant Center
Duke Department: Surgery – Transplant
Duke-NUS/SingHealth Faculty: Kee, Terence, MD
Adjunct Assistant Professor, Duke NUS; Associate Consultant, Renal Medicine Singapore General Hospital
Singapore Program: SGH - Renal and Transplant; DNUS
Project Title: Immune Profile of Race and Rejection after Kidney Transplantation
Duke Faculty: Kuo, Anthony, MD
Assistant Professor, Departments of Ophthalmology &Biomedical Engineering
Duke Department: Ophthalmology Corneal Ophthalmology
Duke-NUS/SingHealth Faculty: Schmetterer, Leopold, PhD
Head, Ophthalmic Imaging, SERI; Professor of Ophthalmology, Nanyang Technological University
Singapore Program: SERI – Ophthalmology
Project Title: Innovations in High Resolution Corneal Imaging for the Clinic
Duke Faculty: Orlando, Lori Ann, MD
Associate Professor, Department of Medicine - General Internal Medicine
Duke Department: Medicine – General Internal Medicine
Duke-NUS/SingHealth Faculty: Wu, Rebekah Ryanne, MD
Assistant Professor of Medicine & Health Services & Systems Research, DNUS
Singapore Program: DNUS - Health Services & Systems Research
Project Title: Development and clinical implementation pilot of an oncology-specific risk assessment tool in Singapore
Duke Faculty: Permar, Sallie, MD, PhD
Associate Professor of Pediatrics, Department of Pediatrics - Infectious Diseases
Duke Department: Pediatrics Infectious Diseases
Duke-NUS/SingHealth Faculty: Ooi, Eng Eong, BMBS, PhD
FRCPath Professor & Deputy Director, Programme in Emerging Infectious Diseases, DNUS
Singapore Program: DNUS – EID
Project Title: Relationship between maternal humoral immunity and fetal outcome of maternal Zika virus infection
Duke Faculty: Sullivan, Keith, MD
James B Wyngaarden Professor of Medicine, Department of Medicine - Hematological Malignancies & Cellular Therapy
Duke Department: Medicine Hematological Malignancies & Cellular Therapy
Duke-NUS/SingHealth Faculty: Grigoropoulos, Nicholas, PhD, MBBS, MRCP, FRCPath
Consultant, Department of Haematology, SGH; Assistant Professor, DNUS
Singapore Program: SGH - Haematology;DNUS
Project Title: Investigation of clonal hematopoiesis as a risk factor for therapy-related myelodysplastic syndrome and acute myeloid leukemia in patients with systemic sclerosis undergoing myeloablative autologous hematopoietic stem cell transplantation
Duke Faculty: Xian, Ying, PhD
Assistant Professor of Neurology, Department of Neurology and Assistant Professor of Medicine - Clinical Pharmacology
Duke Department: Neurology -Neurocritical Care; Medicine – Clinical Pharmacology
Duke-NUS/SingHealth Faculty: De Silva, Deidre, MBBS, MRCP, FAMS
Associate Professor, DNUS; Senior Consultant Neurologist, NNI e
Singapore Program: DNUS; NNI
Project Title: Improving Door-to-Needle Times for Tissue Plasminogen Activator Administration in Acute Ischemic Stroke in Singapore: A Pilot Study