Basic Science News at Duke School of Medicine

Can Scientists Learn to Prevent Brain Tumors?

David Ashley, PhD, FRACP, MBBS, the Rory David Deutsch Distinguished Professor of Neuro-Oncology and director of the Preston Robert Tisch Brain Tumor Center at Duke, calls his choice to focus his career on brain cancers "a compulsion to defeat this terrible problem."  

Chasing New Targets in Parkinson’s Disease

Colin Duckett, Vice Dean for Basic Science, led a discussion with premier researchers taking a a closer look at the fundamental biology of Parkinson’s disease during the March 30 Dean’s Distinguished Research Series.

Collaboration Seeks Genetic Clues to Chronic Lung Disease

Idiopathic pulmonary fibrosis (IPF) is a disease that causes scarring on the lungs. Over time, as more scarring occurs, patients experience decreased lung function and difficulty breathing. Once diagnosed, most patients die within five years. 

Study Reveals How UV Radiation May Drive Melanoma

Raluca Gordân, PhD, and team investigated how transcription factors may affect the production of genetic mutations, or mutagenesis, by binding to the wrong sites after being exposed to ultraviolet (UV) radiation.

Closing in on New Treatments for Prostate Cancer

One in seven men are diagnosed with prostate cancer during their lifetimes. For those who aren't cured by surgery or radiation, treatments that suppress the male hormone androgen can temporarily stop the disease from progressing. But at some point, hormone-based treatments stop working for most men.  

New Therapy for Advanced Breast Cancer Has Roots in Duke Lab

On January 27, 2023,  the Food and Drug Administration approved a new targeted therapy for hard-to-treat advanced breast cancers. Its development was made possible by research and advocacy from the lab of Donald McDonnell, PhD, in the Department of Pharmacology and Cancer Biology.