lou.defrate@duke.edu
919-681-9959
Medical Sciences Research Building I, 203 Research Drive, Room 379
DUMC Box 3093, Durham, NC 27710
The DeFrate Lab Site
The DeFrate laboratory applies engineering principles to study clinically-relevant problems involving the musculoskeletal system. In particular, they evaluate in vivo biomechanics using advanced radiographic and MRI techniques, which enables them to investigate soft tissue structure, composition, and function in healthy and diseased states.
Selected Publications and Grants
Publications
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Andress, B., Kim, J. H., Cutcliffe, H. C., Amendola, A., Goode, A. P., Varghese, S., … McNulty, A. L. (2021). Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding. J Orthop Res, 39(10), 2177–2186. https://doi.org/10.1002/jor.24954
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Heckelman, L. N., Wesorick, B. R., DeFrate, L. E., & Lee, R. H. (2021). Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans. J Biomech, 128, 110707. https://doi.org/10.1016/j.jbiomech.2021.110707
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Coppock, J. A., Danyluk, S. T., Englander, Z. A., Spritzer, C. E., Goode, A. P., & DeFrate, L. E. (2021). Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test. J Biomech, 121, 110392. https://doi.org/10.1016/j.jbiomech.2021.110392
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Englander, Z. A., Lau, B. C., Wittstein, J. R., Goode, A. P., & DeFrate, L. E. (2021). Patellar Tendon Orientation and Strain Are Predictors of ACL Strain In Vivo During a Single-Leg Jump. Orthop J Sports Med, 9(3), 2325967121991054. https://doi.org/10.1177/2325967121991054
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Crook, B. S., Collins, A. T., Lad, N. K., Spritzer, C. E., Wittstein, J. R., & DeFrate, L. E. (2021). Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees. J Biomech, 116, 110210. https://doi.org/10.1016/j.jbiomech.2020.110210
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Kim-Wang, S. Y., Scribani, M. B., Whiteside, M. B., DeFrate, L. E., Lassiter, T. E., & Wittstein, J. R. (2021). Distribution of Bone Contusion Patterns in Acute Noncontact Anterior Cruciate Ligament-Torn Knees. Am J Sports Med, 49(2), 404–409. https://doi.org/10.1177/0363546520981569
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Collins, A. T., Hu, G., Newman, H., Reinsvold, M. H., Goldsmith, M. R., Twomey-Kozak, J. N., … Karner, C. M. (2021). Obesity alters the collagen organization and mechanical properties of murine cartilage. Sci Rep, 11(1), 1626. https://doi.org/10.1038/s41598-020-80599-1
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Cutcliffe, H. C., & DeFrate, L. E. (2021). Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties. Methods Mol Biol, 2230, 199–215. https://doi.org/10.1007/978-1-0716-1028-2_12
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Cutcliffe, H. C., Davis, K. M., Spritzer, C. E., & DeFrate, L. (2020). The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function. Ann Biomed Eng, 48(12), 2901–2910. https://doi.org/10.1007/s10439-020-02558-1
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Collins, A. T., Kulvaranon, M., Spritzer, C. E., McNulty, A. L., & DeFrate, L. E. (2020). The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain. Orthop J Sports Med, 8(12), 2325967120964468. https://doi.org/10.1177/2325967120964468
Grants
- Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury (Co-Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2021-2026 More info
- In Vivo Knee Motion and ACL Biomechanics During Dynamic Activities (Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
- Mechanical Biomarkers of Chronic Low Back Pain (Co-Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
- Weight loss, in vivo cartilage mechanics, and joint health (Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2023 More info
- Duke CTSA (TL1) (Mentor), awarded by National Institutes of Health, administered by Institutes and Centers, 2018-2023 More info
- Metabolomic & Radiographic Markers of Fracture Risk Among Older Adults with Diabetes (K23) (Co-Mentor), awarded by National Institutes of Health, administered by Medicine, Endocrinology, Metabolism, and Nutrition, 2018-2023 More info
- Exercise-induced recovery of intervertebral disc health (Collaborator), awarded by National Institutes of Health, administered by Orthopaedics, 2020-2022 More info
- Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk) (Co Investigator), awarded by National Institutes of Health, administered by Duke Clinical Research Institute, 2017-2022 More info
- Comparison of In-Vivo Knee cartilage vs. augmented anterolateral ligament reconstruction (Investigator), awarded by Piedmont Orthopedic Foundation, administered by Orthopaedics, 2019-2021 More info
- Age-related alterations in the in vivo mechanical function of the spine (Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2017-2020 More info