IPE Building Office 5241
Dr. Pastva is a clinical scientist, a basic scientist, an educator and a mentor in the DPT Program. She is also an Assistant Director in the Duke Health Center for Interprofessional Education and Care. In addition to her primary faculty appointment in the DPT Division, she holds secondary appointments in the Department of Medicine, Department of Cell Biology, and the Department of Population Health Sciences. She is also a Senior Fellow in the Duke Center for the Study of Aging and Human Development and a Duke Pepper Older American Independence Center (OAIC) Scholar. With expertise in physical rehabilitation, exercise physiology, and cellular and molecular physiology, she understands bodily processes at the functional level, organ physiological level, and cellular and molecular level; this skill set is vital to leading or collaborating on projects that involve physical activity and exercise interventions and incorporate measures of physical reserve, especially for medically complex and/or older adults, and for translating relationships among biophysiological data and functional performance outcomes. Dr. Pastva is also interested in the use of simulation and team-based learning principles in physical therapy and interprofessional curricula.
- 1991 B.S. Physical Therapy, University of Scranton, Scranton, PA
- 1994 M.A. Applied Physiology, Teachers College, Columbia University, New York, NY
- 1998-2000 Doctoral Student, Applied Physiology Teachers College, Columbia University
- 2004 Ph.D. Program, Cellular and Molecular Physiology, University of Alabama, Birmingham (UAB)
- 2004-2006 Post-doctoral Fellowship, Department of Cell Biology, Duke University Durham, NC
- PT 623 Cardiopulmonary Patient Management, Summer Semester, Course Director and Instructor
- PT 724 Evidence-Based Practice Capstone, Instructor
- PT 639 Foundational Cardiovascular and Pulmonary
- APCs in Complex Patient Management in Cardiovascular and Respiratory Rehabilitation
- PT 741 IPE Moral Moments in Medicine
- Expertise in management of patients with disorders of the cardiovascular and pulmonary systems.
- Steering Committee and Mentor, DUHS Cardiovascular and Pulmonary PT Residency Program.
Dr. Pastva's scholarly pursuits cross three areas of investigation:
- Basic Science. Dr. Pastva studies the immune regulatory properties of pulmonary surfactant, a lipoprotein complex produced by alveolar epithelial cells and clara cells in the lungs that regulates immune host defense. She also studies the mechanisms by which aging and chronic diseases affect immune system and skeletal muscle function.
- Clinical Science. She bridges her expertise in physical therapy and physiology to investigate rehabilitation strategies for optimizing the health and function of individuals living with chronic cardiopulmonary diseases and/or surviving critical illness. In these experiments, Dr. Pastva is investigating novel therapeutic techniques that can be implemented either early in hospitalization or after hospitalization to mitigate the physical and cognitive impairments that can accompany acute or acute on chronic illness.
- Education. She explores pedagogical strategies such as team-based learning and low-and high-fidelity simulation in health professions curricula to address clinical practice expectations in aging and acute illness.
She has participated as a clinician-scientist at the principle investigator and co-investigator levels on university-, foundation-, and NIH-funded projects where she developed or assisted in the development of the innovative rehabilitative strategies for medically complex patients aimed at improving patient-centered outcomes of physical function, quality of life, and healthcare utilization. She regularly presents her research findings at inter/national conferences of societies such as the American Physical Therapy Association and American Thoracic Society. She serves on the American Physical Therapy Association’s ICU Rehabilitation Clinical Guideline Development Group and on the Research Committee of its Cardiovascular and Pulmonary Section.
Nelson, M Benjamin, Olivia N. Gilbert, Pamela W. Duncan, Dalane W. Kitzman, Gordon R. Reeves, David J. Whellan, Robert J. Mentz, et al. “Intervention Adherence in REHAB-HF: Predictors and Relationship With Physical Function, Quality of Life, and Clinical Events.” J Am Heart Assoc 11, no. 11 (June 7, 2022): e024246. https://doi.org/10.1161/JAHA.121.024246.More info
Lew, Meagan V., Yi Ren, Yen P. Lowder, Sharareh Siamakpour-Reihani, Sendhilnathan Ramalingam, Kristi M. Romero, Jillian C. Thompson, et al. “Geriatric Assessment Reveals Actionable Impairments in Hematopoietic Stem Cell Transplantation Candidates Age 18 to 80 Years.” Transplant Cell Ther, May 17, 2022. https://doi.org/10.1016/j.jtct.2022.05.018.More info
Freburger, Janet K., Amy M. Pastva, Sylvia W. Coleman, Kennedy M. Peter, Anna M. Kucharska-Newton, Anna M. Johnson, Matthew A. Psioda, et al. “Skilled Nursing and Inpatient Rehabilitation Facility Use by Medicare Fee-for-Service Beneficiaries Discharged Home After a Stroke: Findings From the COMPASS Trial.” Arch Phys Med Rehabil 103, no. 5 (May 2022): 882-890.e2. https://doi.org/10.1016/j.apmr.2021.10.015.More info
Mayer, Kirby P., Amy M. Pastva, Gaixin Du, Sarah P. Hatchett, Mingguang Chang, Angela N. Henning, Baz Maher, Peter E. Morris, and Joseph B. Zwischenberger. “Mobility Levels With Physical Rehabilitation Delivered During and After Extracorporeal Membrane Oxygenation: A Marker of Illness Severity or an Indication of Recovery?” Phys Ther 102, no. 3 (March 1, 2022). https://doi.org/10.1093/ptj/pzab301.More info
Chew, Derek S., Yanhong Li, Michel Zeitouni, David J. Whellan, Dalane Kitzman, Robert J. Mentz, Pamela Duncan, et al. “Economic Outcomes of Rehabilitation Therapy in Older Patients With Acute Heart Failure in the REHAB-HF Trial: A Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 7, no. 2 (February 1, 2022): 140–48. https://doi.org/10.1001/jamacardio.2021.4836.More info
Murray, Evan M., David J. Whellan, Haiying Chen, Alain G. Bertoni, Pamela Duncan, Amy M. Pastva, Dalane W. Kitzman, and Robert J. Mentz. “Physical Rehabilitation in Older Patients Hospitalized with Acute Heart Failure and Diabetes: Insights from REHAB-HF.” Am J Med 135, no. 1 (January 2022): 82–90. https://doi.org/10.1016/j.amjmed.2021.08.001.More info
Whellan, David J., Dalane W. Kitzman, Haiying Chen, Michael B. Nelson, Amy M. Pastva, Melissa McCarey, Pamela W. Duncan, Robert J. Mentz, and Shelby D. Reed. “Characterizing Changes in Quality of Life and in Older Patients With Acute Decompensated Heart Failure Enrolled in a Rehab Intervention Clinical Trial.” In Circulation, Vol. 144, 2021.More info
Pandey, Ambarish, Amy M. Pastva, Pamela W. Duncan, Michael Nelson, Dalane W. Kitzman, David J. Whellan, Robert J. Mentz, Haiying Chen, Bharathi Upadhya, and Gordon R. Reeves. “Relationship Between Baseline Frailty Status and Benefits of a Novel Multidomain Physical Rehabilitation Intervention Among Older Patients Hospitalized With Acute Decompensated Heart Failure: The REHAB-HF Trial.” In Circulation, Vol. 144, 2021.More info
Mentz, Robert J., David J. Whellan, Gordon R. Reeves, Amy M. Pastva, Pamela Duncan, Bharathi Upadhya, M Benjamin Nelson, et al. “Rehabilitation Intervention in Older Patients With Acute Heart Failure With Preserved Versus Reduced Ejection Fraction.” Jacc Heart Fail 9, no. 10 (October 2021): 747–57. https://doi.org/10.1016/j.jchf.2021.05.007.More info
Kitzman, Dalane W., Amy M. Pastva, and Robert J. Mentz. “Physical Rehabilitation in Patients with Heart Failure. Reply.” N Engl J Med 385, no. 14 (September 30, 2021): 1340–41. https://doi.org/10.1056/NEJMc2113494.More info
Awards and Honors
• 2008 National Institute of Allergy and Infectious Disease's K08 Mentored Clinical Scientist Research Career Development Award
• 2009 Scholarship to present at the International Conference of the American Thoracic Society
• 2011 Selected Participant, Course in Scientific Leadership and Management, Sponsored by Dean Nancy Andrews, Duke University School of Medicine
• 2011 Claude D. Pepper Scholar Award in Aging Research, Duke University Pepper Center
• 2013 Appointed Senior Fellow, Duke Center for the Study of Aging and Human Development
• 2014 Appointed, Clinical Practice Guideline Development Group – Physical therapy management of critically ill patients in the ICU, American Physical Therapy Association, Cardiovascular and Pulmonary Section
• 2014 American Thoracic Society Foundation Unrestricted Grant award recipient
• 2015 Best Platform Presentation, APTA Cardiovascular and Pulmonary Section, Combined Sections Meeting
• 2015 Best Student Presentation, APTA Cardiovascular and Pulmonary Section, Combined Sections Meeting (awarded to her mentees)
• 2015 Best Student Presentation, Duke DPT Capstone Day (awarded to her mentees)
• 2015 Research Podium Award, Gerontological Advanced Practice Nurses Association
• 2017 Nominated, Duke School of Medicine Master Clinician/Teacher Award
• 2017 New and Noteworthy, Clinical Practice Today e-newsletter from Duke Health, Orthopaedics Issue and General Medicine Issue, Supine cycle allows patients to exercise in ICU,
• 2017 Nominated/Appointed, Duke Chancellor’s Translating Duke Health Cardiovascular Initiative Steering Committee
• 2018 Selected Participant, Interprofessional Simulation Faculty Development Workshop, Sponsored by Duke AHEAD, Duke University School of Medicine
• 2019 Society for Healthcare In Simulation, Certified Healthcare Simulation Educator (CHSE)
• 2020 Selected Participant, Academic Leadership, Innovation, and Collaborative Engagement (ALICE) Program for women faculty development, sponsored by the Office of Faculty, Duke University School of Medicine
• 2020 Best Research Platform Presentation, APTA Cardiovascular, and Pulmonary Section, Combined Sections MeetingSelected Grants
CYCLE RCT: International RCT of early in-bed cycling with mechanically ventilated patients
- Awarded by: Canadian Institute of Health Research
- Goal: Determine whether in-bed cycling will improve clinical/functional outcomes and health service utilization compared to usual care in those who are critically ill.
- Role: Steering Committee/Duke Site Principle Investigator
Claude D. Pepper Older Americans Independence Center
- Awarded by: National Institutes of Health, National Institute for Aging (2016-2021)
- Goal: Understand and optimize physiologic reserve and physical resilience in older adults.
- Role: Co-Investigator/Physical Measures Core
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients
- Awarded by: National Institute for Aging
- Goal: Multicenter randomized clinical trial (Wake Forest, Duke, Thomas Jefferson) to test whether, in addition to standard care, a progressive, multi-domain rehabilitation intervention administered to elders with acute decompensated heart failure beginning early in hospitalization and continuing for 3 months will improve functional and utilization outcomes.
- Role: Steering Committee/Co-Investigator/Intervention Lea
Physical therapist management of critically ill patients in intensive care
- Awarded by: American Physical Therapy Association (2015-2018)
- Goal: Develop the clinical practice guidelines for the physical therapist management of critically ill patients in the intensive care setting.
- Role: Core Development Group
Early supported discharge for improving functional outcomes after stroke
- Awarded by: Patient-Centered Outcomes Research Institute
- Goal: Determine whether transitional care and early supported discharge for stroke patients who go home directly from the hospital improves patients’ daily function compared with usual care.
- Role: Steering Committee/Co-Investigator/Intervention Lead
Duke Roybal Center – Pilot Project HF Active
- Awarded by: National Institute of Aging
- Goal: Develop a tailored physical activity toolkit for older adults with heart failure.
- Role: Co-Principle Investigator (with K Hall)
- Awarded by: Oncology Nurse Foundation
- Goal: Test the efficacy of Build Stamina, a 3-month multidomain exercise program, improves function and quality of life in adults with acute leukemia.
- Role: Co-Investigator/Intervention Lead
ERiCC: Early Rehabilitation in Critical Care
- Awarded by: American Thoracic Society
- Goal: Determine whether functional electrical stimulation-assisted cycling will improve physical and neurocognitive outcomes compared to usual care in those who are critically ill.
- Role: Principle Investigator
- Awarded by: National Health and Medical Research Council, Australia
- Goal: Multi-site randomized clinical trial (University of Melbourne/Austin Health, Duke, Johns Hopkins, Royal Brisbane) to determine whether functional electrical stimulation-assisted cycling will improve physical and neurocognitive outcomes compared to usual care in those who are critically ill.
- Role: Steering Committee/Duke Site Principle Investigator
Impact of age on outcomes associated with early mobilization in medical intensive care
- Awarded by: Gerontological Advanced Practice Nurses Association Foundation
- Goal: Retrospective trial to assess the impact of age on clinical and functional outcomes in patients who were critically ill in the medical intensive care unit and who participated in an early mobility program.
- Role: Co-Principle Investigator (with V.Sabol)
The in vivo role of surfactant protein A in allergen-mediated lung disease.
- Awarded by: National Institute for Allergy and Infectious Disease
- Goal: To determine the role of surfactant protein A in modulating the transition between innate and adaptive immunity and influencing airway physiology using murine models and cell isolates.
- Role: Principle Investigator