Bastiaan Driehuys

Bastiaan Driehuys
Professor of Radiology
Third Year Mentor - Molecular Medicine Study Program (MolMed)
Third Year Mentor - Radiology, Radiation Oncology, and Medical Physics (RROMP)
Campus mail: 161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Phone: (919) 684-7786

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Education and Training

  • Princeton University, Ph.D. 1995


3He MRI in mouse models of asthma.

In the study of asthma, a vital role is played by mouse models, because knockout or transgenic methods can be used to alter disease pathways and identify therapeutic targets that affect lung function.