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Lori Ann Orlando, MD, MHS is an Associate Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. Her major research interests are decision-making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. She has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment, and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. She is currently testing methods for integrating patient preferences and decision-making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.