Pathology Grand Rounds - ctDNA Genomics and Beyond Genomics: An Approach of Inferring Epigenetically Diverse Phenotypic Subtypes of Prostate Cancer

At the conclusion of this activity, learners should be able to: * Nucleosome profiles from ctDNA can accurately depict prostate cancer epigenetic subtypes/phenotypic subtypes * With our approach we can derive AR activity signature from ctDNA * It is feasible to use AS activity signature as clinical determinant for standard of care antiandrogen therapy responses * Potential tool for precision medicine for monitoring therapy-induced disease evolution