Crypts, Organoids and Cancer - the Journey of the Wnts


David Virshup, MD


Dr. David Virshup
Professor and Director, Program in Cancer and Stem Cell Biology, Duke-NUS Medical School Singapore; Professor of Paediatrics, Duke University, Durham, NC

Hosted by Department of Cell Biology, Duke University

 Virshup discussed recent findings from his lab including:

  • Structural insights into the dedicated proteins PORCN and WLS/ Evi in sending cells that acylate and deliver Wnts to the plasma membrane.
  • How telocytes from the intestinal stroma deliver Wnts to stem cells in organoids.
  • Insights into downstream Wnt signaling gleaned from studies of small molecule PORCN inhibitors in Wnt-addicted cancers.