Unlocking the fundamental rules of immune control to facilitate the most precise personalized medicine and the broadest population-based vaccine and disease prevention strategies
- Autoimmune diseases occur when the immune system mistakenly identifies certain cells of the body as foreign like:
- Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arthritis, Systemic Lupus Eythematosus
- Diseases can also occur when the immune system fails to distinguish healthy cells from unhealthy cells:
- Cancer & Immune Deficiency Diseases
- The immune system is continuously assessing the body and making decisions about what belongs and what does not. The ability to finely control the immune system remains a challenge in modern medicine.
- Control the immune system to:
- Understand differing outcomes;
- Harness as therapeutic strategy.
- Two Lines of Investigation:
- Define population norms for immunity.
- Link basic immune knowledge to the clinic.
Local Impact at Duke
- Improve the ability to transplant cells, tissues, and organs without the effects of non-specific immunosuppressive drugs.
- Develop better treatments for cancer with a focus on curative cancer immunotherapy.
- Enhance treatment and prevention of autoimmune diseases, such as Type 1 Diabetes, Multiple Sclerosis, and Lupus.
- Create a greater impact on developing preventative therapies:
- HIV vaccines
- Cancer vaccine development
- Vaccines against new infectious diseases
- Enhance the ability to link immune responsiveness to disease susceptibility.
- Improved the ability to anticipate disease, maintain health, and manage populations.