Brain disorders pose a daunting personal, societal and financial burden for people and their families around the globe. Current research approaches have focused on identifying and studying pharmacological targets and therapies. Yet, critical opportunities exist for innovative exploration of the potential impact that could be achieved with a blend of behavioral, electrical, surgical, and pharmacological strategies.
Ultimately, effective multi-modal and therapeutic approaches to brain disorders must fundamentally enhance neuroplasticity and brain resilience. The goal is to detect and forestall underlying disease processes prior to the onset of symptoms in diseases such as Alzheimer’s, Parkinson’s and other neurodegenerative disorders and boost repair of disrupted brain circuits once symptoms appear.
Duke's clinical research efforts will focus on the discovery of new early biomarkers for brain disease that will enable intervention between the onset of disease and before the appearance of symptoms.