Translating Duke Health is a multiyear, multidisciplinary program to capitalize on our collective strengths in research, clinical care, and population health to address major health challenges. One of the five focus areas, the Immunology & Transplant Initiative, is focused on understanding the fundamental rules of immune control.
Duke researchers in transplantation are working to define the mechanisms of immune control to prevent organ rejection and improve survival in adult and pediatric transplant recipients. By identifying the immune signatures of different patient populations, this research will lead to novel tailor-made treatments unique to each patient’s immune system.
This precise, personalized medicine aims to promote graft acceptance in recipients of donor organs, thereby minimizing the need for patients to take long-term immunosuppressive drugs. Additionally, research teams are studying novel organ preservation methods to expand the donor pool and reduce time on the organ wait list. These cutting-edge treatments and diagnostics will save lives by making transplantation more widely accessible for patients.
Transplant Research Laboratories
- Cardiothoracic Surgery Translational Research Laboratory
Directors: Carmelo Milano, MD, and Dawn Bowles, PhD, Department of Surgery
- Knechtle Laboratory
Director: Stuart Knechtle, MD, Department of Surgery
- Laboratory of Immune Management
Director: Allan Kirk, MD, PhD, Department of Surgery
- Laboratory of Vascularized Composite Allotransplantation
Director: Linda Cendales, MD, Department of Surgery
- Barbas Laboratory
Director: Andrew Barbas, MD, Department of Surgery
- Chambers Laboratory
Director: Eileen Chambers, MD, Department of Pediatrics
- Luo Laboratory
Director: Xunrong Luo, MD, Department of Medicine
Collaborating Faculty Members
- Matthew Hartwig, MD, Associate Professor of Surgery, Department of Surgery
- Jaewoo Lee, PhD, Assistant Professor of Surgery, Department of Surgery