Past Voucher Projects

2017 Awards

  • A genome-wide screen to identify suppressors of a GBA model of Parkinson Disease
  • Better than drugs: Neuroprotection by exercise in a mouse model of menopause in Alzheimer's Disease
  • Connectivity-based iTBS to treat memory deficits in early Alzheimer's Disease
  • CRISPR epigenome editing screen to identify genes required for recurrent tumor cell survival
  • Defining the optimal patient population for complement factor H antibody therapy
  • Designing "Silent Killers" for CAR T immunotherapy
  • Developing genomic resources for quantitative genetics of recombination in Drosophila
  • Enhancing mitochondrial quality control programs to improve liver transplantation
  • Formation of Watson-Crick-like DNA mismatches and their role in replication errors
  • Identification of signaling pathways downstream of CaMKK2 relevant to cancer pathogenesis
  • Metal nanowire flow-through electrodes
  • Modifying the microbiota to improve hematopoietic stem cell transplant outcomes
  • Novel 3D brain tissue assay for glioma intratumoral heterogeneity
  • Pathogen mobilomes as gateways to antibiotic resistance and prevalence
  • Preventing memory dysfunction after surgery with a novel pro-resolving peptide from Annexin-A1
  • Single-cell lineage tracing the emergence of cancer drug resistance
  • Ufmylation regulates antiviral innate immunity and interferon induction
  • Using TRAP-Seq to identify molecular signatures of neurons orchestrating the anesthesia state

2016 Awards

  • A mouse to map gut feelings in the brain
  • Activity-dependent mRNA methylation in the neuronal transcriptome
  • Annotation of transposable elements in the genome of Cryptococcus neoformans
  • Counteracting age-related skeletal muscle stem cell dysfunction
  • Crystallographic characterization of peptide and small molecule inhibitors of TrkB signaling
  • Define antifungal drug action mechanisms through targeted proteomics in Aspergillus fumigatus
  • Discovery and characterization of small-molecule probes for PRMT6
  • HIV-associated neurocognitive impairment: The role of drug abuse and neuroinflammation
  • Hypoxia-inducible factors and radiation therapy
  • Identification of novel microbial pH-sensing proteins
  • Identification of polymorphisms in STIM1 associated with obesity-related adverse labor outcomes
  • Identification of transcriptional mediators in Hedgehog-induced macrophage M2-polarization
  • Immunophenotyping of blood and sputum in the HIV-infected non-asthmatic patient
  • Metabolic imaging of tumor regression, dormancy, and recurrence
  • Phosphoproteomic study to identify regulatory nodes in scoliosis
  • Phosphoregulation of Caskin 2 in endothelial cells
  • Predictive biomarkers for arteriovenous fistula outcomes in dialysis access patients
  • Sequencing technology for rapid detection of fastidious and resistant infectious agents
  • Spatiotemporal evaluation of inflammasome activation during the development of an autoimmune disease
  • Specialized ribosomes control anti-viral response programs
  • Transcriptome analysis of microcephaly mutants

2015 Awards

  • A novel blood-based diagnostic for early stage pancreatic cancer
  • A pilot study of the aspirin response signature as a marker of preeclampsia risk in women with lupus
  • Assessment of pharmacokinetics and efficiency of novel stealth Paclitaxel nanoparticles
  • Assessment of T-cell exhaustion in chronic viral infection following solid organ transplant
  • Characterizing the effects of genetic variation on osmo-signaling dynamics in yeast
  • Characterizing the role of rare IL-15R ✓ variants in the pathogenesis of focal segmental glomeruloscl
  • Comparative transcriptomics of two Ipomoea species
  • Crystallographic studies of a novel antibiotic target in lipid A biosynthesis
  • Crystallographic studies of the interaction between the EBV EBNA2 and host RBPJ proteins
  • Development of in vivo metastasis models for hormone receptor-positive breast and prostate cancer
  • Development of a novel mouse model to study the role of IRGM in colitis and septic shock
  • Discovery and characterization of innate immune regulatory kinases during HCV infection
  • Discovery of a novel protease involved in cellular senescence by using SILAC based MS
  • Does 129Xenon-MRI have the potential to diagnose patients with pulmonary arterial hypertension?
  • Establishing a complex trait mapping panel in yeast using private haplotype barcoding
  • ​Evolutionary genomics of DNA methylation in the baboon genus Papio
  • Examining the genomic basis of adaptation to the gut niche
  • Generation of an inducible, rod-specific Cre-recombinase knock-in mouse
  • Genetic tools to dissect mammalian heart regeneration
  • Identification of BRCA1 synthetic lethal genes via microarray analysis of genome-wide shRNA screens
  • Identification of contractile and metabolic proteins in primate jaw muscle
  • Identifying the factors of in vitro-derived dendritic cells that mediate enhanced immunogenicity
  • Immune phenotyping: Infantile Pompe Disease
  • Injectable brachytherapy enhances EPR effect by modifying tumor microenvironment
  • Intravenous lidocaine for myocardial protection during cardiac surgery with cardiopulmonary bypass
  • Investigation of endocytosis involved in electrotransfection using transmission electron microscopy
  • Leveraging natural variation in Salmonellae to elucidate the role of IL-10 in disease
  • Molecular deconstruction of human circulating pathogenic autoantibodies
  • ​Novel approaches for the study of cardiovascular snoRNA
  • Novel exercise training in elderly pre-diabetics to improvee immune function and inflammation
  • Phospho-proteomics of the somatic, activating mutation in GNAQ in Sturge Weber Syndrome
  • Placental dysregulation and inflammation in severe congenital cytomegalovirus infection
  • Project BrainTumorSlice: Screening for chemo-radiosensitization targets in 3D models of glioma
  • Protein interactome analysis of synthetic epigenome editing tools
  • Quantification of Pseudomonas aeruginosa cell biofilms on human lung cells
  • Spatial clustering of P. falciparum malaria parasite transmission
  • Structural and functional studies of staphylococcal protein A
  • Targets of transcriptional kinase CDK12 and its role as a tumor suppressor
  • The gut as the origin of Parkinson's disease
  • The molecular epidemiology of MDR E. coli and Klebsiella using whole genome sequencing
  • Transcriptional profiling of sciatic nerve samples from traumatic amputees
  • Transcriptional profiling of spinal cord infiltrates in acute lymphoblastic leukemia
  • Transcriptome analysis of microcephaly mutants
  • Transcriptome analysis of pathologic myeloid cells in the mouse neurodegenerating retina
  • Transcriptome profiling of poison ivy-induced allergic contact dermatitis by microarray
  • ​Transcriptomics in a non-model organism: Viral hijacking of an ancestral fungal cell cycle
  • Tri-SNCA iPSC-derived cell lines for studying the effect of SNCA overexpression on synucleinopathies
  • ​Understanding 27HC in breast cancer biology using a genome-wide CRISPR screen in a mouse model
  • Whole transcriptome analysis following hypoxia, a comparative study between lemur and human