The Duke University School of Medicine has a strong tradition of genomic discoveries. The Precision Genomics Collaboratory brings together all of the units in Duke focused on genomics research to create a multi-disciplinary community able to tackle challenges in the ever-evolving genomics landscape.


Circos plot illustrating complex fusion between chromosomes 1 (SAMD13), 4 (G3BP2), and 10 (FGFR2). Additional fusions are also indicated, and a complete annotation of fusions within this model can be found in the supplementary file. Each arc represents a predicted gene fusion event, where the width of the arc is proportional to the strength of the evidence supporting the prediction. Blue arcs represent fusions between chromosomes and red arcs represent fusions within chromosomes.Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies

Kris Wood, Kouros Owzar, Joshua Granek, David Hsu and colleagues generated patient-derived models of fibroblast growth factor receptor 2 (FGFR2) fusion-positive Intrahepatic cholangiocarcinoma (ICC). ICC is a highly aggressive primary liver cancer that is nearly universally fatal. The models created can be used to not only test standard-of-care therapeutic strategies but also explore potential other therapies to help treat ICC.
Read full text in NPJ Precision Oncology

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