Featured Publications

blood based host gene expression assay

RT-PCR-based 36-gene signature performance over time

Researchers in the Center for Applied Genomics and Precision Medicine assessed the ability of transcriptomic biomarkers to identify naturally acquired respiratory viral infection before symptoms appear.

Read full text in The Lancet

cardiovascular disorders

Identification of Undetected Monogenic Cardiovascular Disorders

A collaboration between DMPI, Division of Cardiology, Center for Applied Genomics and Precision Medicine as well as Regeneron Genetics Center and Vanderbilt Medical Center shows the large burden of undetected monogenetic cardiovascular disorders.

Read full text in the Journal of the American College of Cardiology

Endothelium stained with anti-CD31 (green) and red blood cell autofluorescence within the lumen of the CCMs demonstrates the lack of acute hemorrhage into the brain parenchyma in this model (scale bars: 50 µm). r–t B lymphocytic infiltrates (arrows) were observed in CCMs at each time point (scale bars: 50 µm)

Novel Murine Models of Cerebral Cavernous Malformations

Doug Marchuk and team developed a genetic mouse model of cerebral cavernous malformations. 

Read full text in Angiogenesis