Assistant Professor of Cell Biology
Amgen Faculty Mentor
CMB - Cell Biology
Education and Training
- University of Hong Kong (China), Ph.D. 2011
Yarui Diao
Publications
A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.
During mouse embryo development, both muscle progenitor cells (MPCs) and brown adipocytes (BAs) are known to derive from the same Pax7+/Myf5+ progenitor cells. However, the underlying mechanisms for the cell fate control remain unclear.
A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.
With <2% of the human genome coding for proteins, a major challenge is to interpret the function of the noncoding DNA.
A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells.
Millions of cis-regulatory elements are predicted to be present in the human genome, but direct evidence for their biological function is scarce.
Chromatin architecture reorganization during stem cell differentiation.
Higher-order chromatin structure is emerging as an important regulator of gene expression.
Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
Alzheimer's disease (AD) is the most common cause of dementia. One of the pathological hallmarks of AD is amyloid β (Aβ) deposition.
MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies.
Alzheimer's disease (AD) is the most common cause of dementia. Amyloid β (Abeta, Aβ) deposition and intracellular tangles are the pathological hallmarks of AD.
miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma found in children and young adults. It is characterized by the expression of a number of skeletal muscle-specific proteins, including MyoD and muscle α-actin.
Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding.
Mitogen-activated protein kinase kinase 6 (MKK6) is a member of the mitogen-activated protein kinase (MAPK) kinase (MAP2K) subfamily that specifically phosphorylates and activates the p38 MAPKs.
Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism.
In mouse skeletal muscles, Pax7 uniquely marks muscle satellite cells and plays some important yet unknown functions at the perinatal stage.
PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.
Skeletal muscle satellite cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced regeneration.