Neil Jonathan Freedman

Neil Jonathan Freedman
Professor of Medicine
Third Year Mentor - Cardiovascular Study Program (CVS)
Third Year Mentor - Clinical Research Study Program (CRSP)
Campus mail: 447 Clin & Res Labs, Durham, NC 27710
Phone: (919) 684-6873

Our work focuses on atherosclerosis-related signal transduction and the genetic bases of atherosclerosis and vein graft failure, both in vitro and in vivo. We investigate the regulation of receptor protein tyrosine kinases by G protein-coupled receptor kinases (GRKs), and the role of GRKs and β-arrestins in atherosclerosis; the role of tumor necrosis factor and its receptors in atherosclerosis; and the role of the dual Rho-GEF kalirin in atherosclerosis. For in vivo modeling of atherosclerosis and neointimal hyperplasia, we use mouse carotid artery bypass grafting with either veins or arteries from gene-deleted or congenic wild type mice, as well as aortic atherosclerosis studies and bone marrow transplantation. To study receptor phosphorylation, signal transduction, and intracellular trafficking, we employ primary smooth muscle cells, endothelial cells, and macrophages derived from knockout mice or treated with RNA interference.

Key Words: atherosclerosis, G protein-coupled receptor kinases, arrestins, desensitization, phosphorylation, platelet-derived growth factor receptors, receptor protein tyrosine kinases, smooth muscle cells, neointimal hyperplasia, Rho-GEF.

Education and Training

  • Harvard University, M.D. 1985
  • Beth Israel Deaconess Medical Center, Medical Resident, Medicine
  • Brigham and Women's Hospital, Research Fellow in Medicine, Medicine
  • Massachusetts Institute of Technology, Visiting Scientist
  • Duke University, Fellow in Cardiology, Medicine

Publications

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