Nazema Yusuf Siddiqui

Associate Professor of Obstetrics and Gynecology

Third Year Mentor - Clinical Research Study Program (CRSP)

Campus mail: 5324 McFarland Drive Suite 310, Box 3912, Durham, NC 27617

Phone: (919) 401-1000

Research on pelvic floor disorders. Specific interests include: 1) pathophysiology of overactive bladder with particular emphasis on epigenetic mechanisms; and 2) studying the urinary microbiome with aging and in women with recurrent urinary tract infection. Additional interests include clinical outcomes research after surgery for prolapse and other pelvic floor disorders.

Education and Training

University of Michigan at Ann Arbor, M.D. 2001
Duke University School of Medicine, M.H.S.C.R. 2010
MetroHealth Medical Center, Cleveland Clinic, Residency, Ob/Gyn
Duke University School of Medicine, Fellow, Female Pelvic Medicine & Reconstructive Surgery, Obstetrics & Gynecology

Selected Grants and Awards

Publications

A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome.

To assess the feasibility of using voided urine samples to perform a DNA methylation study in females with interstitial cystitis/bladder pain syndrome (IC/BPS) as compared to age- and race-matched controls.

A Model for Predicting the Risk of De Novo Stress Urinary Incontinence in Women Undergoing Pelvic Organ Prolapse Surgery

A validated translation of a survey for measuring incontinence knowledge in Chinese-speaking American immigrants.

Urinary incontinence is common amongst Chinese immigrants. These women are a rapidly growing population in the USA who require unique assessment tools due to language barriers.

ADEQUATE COMPENSATION? THE RESPONSE OF BLADDER SMOOTH MUSCLE TO BOTULINUM TOXIN TYPE A IN A RAT MODEL

American Urogynecologic Society Prolapse Consensus Conference Summary Report.

The 2016 American Urogynecologic Society Prolapse Consensus Conference brought together thought leaders in the field of pelvic organ prolapse (POP). The goal was to identify critical areas of need for future research.

Barriers to urinary incontinence care seeking in White, Black, and Latina women.

OBJECTIVE: We compared barriers to urinary incontinence (UI) healthcare seeking between white, black, and Latina women. METHODS: This is a cross-sectional study using a convenience sample of white, black, and Latina women.

Baseline Lower Urinary Tract Symptoms in Patients Enrolled in LURN: A Prospective, Observational Cohort Study.

We described and compared the frequency and type of lower urinary tract symptoms reported by men and women at the time that they were recruited from urology and urogynecology clinics into the Symptoms of Lower Urinary Tract Dysfunction Research Ne

Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence.

Bowel symptoms, pelvic organ prolapse, and sexual dysfunction are common, but their frequency among women with lower urinary tract symptoms (LUTS) has not been well described.

Characterizing the Bladder's Response to Onabotulinum Toxin Type A Using a Rat Model.

OBJECTIVES: The aim of this study was to characterize the response of the rat bladder neuromuscular system to intramural injection of onabotulinum toxin type A (BoNT/A) over 9 weeks using in vivo cystometry (CMG) and in vitro contractility (IVC).

Clinical challenges in the management of vaginal prolapse.

Pelvic organ prolapse is highly prevalent, and negatively affects a woman's quality of life. Women with bothersome prolapse may be offered pessary management or may choose to undergo corrective surgery.

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Nazema Yusuf Siddiqui

Education and Training

Selected Grants and Awards

Publications

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