Ming Chen

Ming Chen
Assistant Professor in Pathology
CMB - Clinical/Other
Campus mail: 905 S Lasalle St, Gsrb1, Rm 2014, Durham, NC 27710
Phone: (919) 684-3641

Our laboratory is interested in understanding the molecular and genetic events underlying cancer progression and metastasis. The focus of our work is a series of genetically engineered mouse models that faithfully recapitulate human disease. Using a combination of mouse genetics, omics technologies, cross-species analyses and in vitro approaches, we aim to identify cancer cell–intrinsic and –extrinsic mechanisms driving metastatic cancer progression, with a long–term goal of developing new therapeutic strategies for preventing and treating metastatic disease. 

Education and Training

  • University of Rochester, Ph.D. 2009
  • Harvard Medical School, Research Fellow in Medicine and Pathology, Beth Israel Deaconness Medical Center


DOK2 inhibits EGFR-mutated lung adenocarcinoma.

Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer therapy trials in huma