1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle
Education and Training
- Carol Davila University of Medicine and Pharmacy (Romania), M.D. 1993
Selected Grants and Awards
- Interface of Mitochondrial Quality Control and Immune Activation in Heart Transplant
- Reversible Immunomodulation as a Strategy for Ischemia Tolerance in Hibernation
- Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications
- Acute Inflammation, Fibrosis in Post Operative Atrial Fibrillation
- Innate immune adaptations of hibernation as a new approach to protection against acute organ injury
- Development of Biomarkers of Aging as a Predictor of AKI Due to Cardiac Surgery
- Cross-species analysis of myocardial susceptibility to perioperative stress
- Genetics Myocardial Adverse Outcomes/Graft Failure-CABG