Education and Training
- University of Washington, Ph.D. 2011
- University of North Carolina at Chapel Hill, Postdoctoral Research Associate, Pharmacology
The manipulation of protein backbone structure to control interaction and function is a challenge for protein engineering.
Computational grafting of functional motifs onto scaffold proteins is a promising way to engineer novel proteins with pre-specified functionalities.
Rational design of proteins with novel binding specificities and increased affinity is one of the major goals of computational protein design.
Experimental autoimmune encephalomyelitis (EAE), a Th1-mediated inflammatory disease of the central nervous system (CNS), is a model of human multiple sclerosis.
Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function.
Rho family GTPases are activated with precise spatiotemporal control by guanine nucleotide exchange factors (GEFs).