Michel Bagnat

Associate Professor of Cell Biology

CMB - Cell Biology

DSCB - Developmental Genetics

Campus mail: 333B Nanaline Duke Building, Durham, NC 27710

Phone: (919) 681-9268

Education and Training

University of Madrid (Spain), Ph.D. 2002

Selected Grants and Awards

Publications

A FORWARD GENETICS APPROACH FOR FISHING NEW REGULATORS OF CFTR AND FLUID SECRETION

A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast.

Recently synthesized proteins are sorted at the trans-Golgi network into specialized routes for exocytosis. Surprisingly little is known about the underlying molecular machinery.

Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants.

Protein O mannosylation is a crucial protein modification in uni- and multicellular eukaryotes. In humans, a lack of O-mannosyl glycans causes congenital muscular dystrophies that are associated with brain abnormalities.

Apicobasal polarity and lumen formation during development

Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.

Cell migration is essential for morphogenesis, organ formation, and homeostasis, with relevance for clinical conditions.

Cell surface polarization during yeast mating

Cell surface polarization during yeast mating.

Exposure to mating pheromone in haploid Saccharomyces cerevisiae cells results in the arrest of the cell cycle, expression of mating-specific genes, and polarized growth toward the mating partner.

Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.

Regulated fluid secretion is crucial for the function of most organs. In vertebrates, the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) is a master regulator of fluid secretion.