Matthew Hirschey

Matthew Hirschey
Associate Professor
Amgen Faculty Mentor
CMB - Clinical/Other
Campus mail: 104775, Room 50-201, Durham, NC 27701
Phone: (919) 479-2315

The Hirschey Lab in the Duke Molecular Physiology Institute, and the Departments of Medicine and Pharmacology & Cancer Biology at Duke University studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.

Education and Training

  • University of California at Santa Barbara, Ph.D. 2006

Selected Grants and Awards



© 2015 by John Wiley & Sons, Ltd. All rights reserved. The mammalian sirtuins are a family of seven NAD+-dependent deacetylase enzymes that regulate a wide range of hepatic functions.

SnapShot: Mammalian Sirtuins.

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan.

Targeting sirtuins for the treatment of diabetes.

Sirtuins are a class of NAD(+)-dependent deacetylases, such as deacetylases, that have a wide array of biological functions. Recent studies have suggested that reduced sirtuin action is correlated with Type 2 diabetes.