Matthew Hirschey

Matthew Hirschey
Associate Professor in Medicine
Amgen Faculty Mentor
CMB - Clinical/Other
Campus mail: 104775, Room 50-201, Durham, NC 27701
Phone: (919) 479-2315

The overall objective of the Hirschey Lab is to better understand metabolism and mitochondrial function, which is important for human health and several human diseases. Their research focuses on metabolism, with a particular interest in how cells use metabolites and chemical modifications to protein in order to regulate metabolism. The lab studies the regulation of this process by a family of enzymes called sirtuins, and how they maintain energy homeostasis. Their work has important implications for diabetes and obesity, cardiovascular disease, cancer, inborn errors, and the aging process itself.

Education and Training

  • University of California at Santa Barbara, Ph.D. 2006

Selected Grants and Awards



© 2015 by John Wiley & Sons, Ltd. All rights reserved. The mammalian sirtuins are a family of seven NAD+-dependent deacetylase enzymes that regulate a wide range of hepatic functions.

SnapShot: Mammalian Sirtuins.

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan.

Targeting sirtuins for the treatment of diabetes.

Sirtuins are a class of NAD(+)-dependent deacetylases, such as deacetylases, that have a wide array of biological functions. Recent studies have suggested that reduced sirtuin action is correlated with Type 2 diabetes.