Matthew Hirschey

Matthew Hirschey
Associate Professor
Amgen Faculty Mentor
CMB - Clinical/Other
Campus mail: 104775, Room 50-201, Durham, NC 27701
Phone: (919) 479-2315

The Hirschey Lab in the Duke Molecular Physiology Institute, and the Departments of Medicine and Pharmacology & Cancer Biology at Duke University studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.

Education and Training

  • University of California at Santa Barbara, Ph.D. 2006

Selected Grants and Awards


A Prob(e)able Route to Lysine Acylation

© 2017 Elsevier LtdNon-enzymatic modification of proteins by acyl-CoA species involved in intermediary metabolism is a possible explanation for widespread protein acylation. In this issue, Kulkarni et al.

Acetate metabolism and aging: An emerging connection.

Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria.