Matthew Hirschey

Matthew Hirschey
Associate Professor in Medicine
Amgen Faculty Mentor
CMB - Clinical/Other
Campus mail: 104775, Room 50-201, Durham, NC 27701
Phone: (919) 479-2315

The overall objective of the Hirschey Lab is to better understand metabolism and mitochondrial function, which is important for human health and several human diseases. Their research focuses on metabolism, with a particular interest in how cells use metabolites and chemical modifications to protein in order to regulate metabolism. The lab studies the regulation of this process by a family of enzymes called sirtuins, and how they maintain energy homeostasis. Their work has important implications for diabetes and obesity, cardiovascular disease, cancer, inborn errors, and the aging process itself.

Education and Training

  • University of California at Santa Barbara, Ph.D. 2006

Selected Grants and Awards


A Prob(e)able Route to Lysine Acylation

© 2017 Elsevier LtdNon-enzymatic modification of proteins by acyl-CoA species involved in intermediary metabolism is a possible explanation for widespread protein acylation. In this issue, Kulkarni et al.

Acetate metabolism and aging: An emerging connection.

Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria.