Jason Locasale

Jason Locasale
Associate Professor of Pharmacology and Cancer Biology

Our research interests are in three interconnected areas:  1) Quantitative biology of metabolism 2) Dietary interventions and metabolic therapeutics in health and cancer.  3) The mechanistic basis between the interaction of metabolism and epigenetics.  Each of these syngergistic areas utilizes the metabolomics technologies we develop along with our expertise in computational and molecular biology.

Education and Training

  • Rutgers University New Brunswick, B.A. 2003
  • Massachusetts Institute of Technology, Ph.D. 2008


A Missing Link to Vitamin B12 Metabolism.

Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B12 levels.