James Valerinano Alvarez

Assistant Professor of Pharmacology & Cancer Biology

Amgen Faculty Mentor

CMB - Pharmacology and Cancer Biology

Education and Training

Pennsylvania State University, B.S. 1999
Harvard Medical School, Ph.D. 2005

Selected Grants and Awards

Publications

Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors.

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated in diverse human tumors and may play a direct role in malignant transformation.

Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.

STAT5a and STAT5b are two highly related transcription factors that control essential cellular functions. Several STAT5 targets are known, although it is likely that most remain uncharacterized.

mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma.

Mouse models that faithfully recapitulate human cancers are indispensable tools for studying the molecular mechanisms of tumorigenesis and testing potential anticancer therapies. In this issue of Cancer Cell, Derksen et al.

NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism

Oncogene addiction: Mouse models and clinical relevance for molecularly targeted therapies

Oncogene pathway activation in mammary tumors dictates FDG-PET uptake.

Increased glucose utilization is a hallmark of human cancer that is used to image tumors clinically.

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.

Somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene EGFR are common in lung adenocarcinoma.

Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes.

With the large number of women diagnosed and treated for breast cancer each year, the importance of studying recurrence has become evident due to most deaths from breast cancer resulting from tumor recurrence following therapy.

Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.

Most deaths from breast cancer result from tumor recurrence, but mechanisms underlying tumor relapse are largely unknown.

Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor.

Somatic mutations in the epidermal growth factor receptor (EGFR) occur frequently in lung cancer and confer sensitivity to EGFR kinase inhibitors gefitinib and erlotinib.

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James Valerinano Alvarez

Education and Training

Selected Grants and Awards

Publications

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