Gregory E. Crawford

Gregory E. Crawford
Associate Professor in Pediatrics
CMB - Clinical/Other
Third Year Mentor - Human Genetics and Genomics Study Program (HGP)
Campus mail: Box 3382 Med Ctr, Durham, NC 27710
Phone: (919) 684-8196

My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate. For the last 30 years, mapping DNase I hypersensitive sites has been the gold standard method to identify the location of active regulatory elements, including promoters, enhancers, silencers, and locus control regions. I have developed technologies that can identify most DNase I hypersensitive sites from potentially any cell type from any species with a sequenced genome. We are combining this data with other wet-lab and computational data types to better understand how these regulatory regions control global gene expression in a set of diverse tissues (normal and diseased) representative of the human body.

Education and Training

  • University of Michigan at Ann Arbor, Ph.D. 2001
  • National Institutes of Health, Postdoctoral Research Fellow, National Human Genome Research Institute

Selected Grants and Awards

Publications

An encyclopedia of mouse DNA elements (Mouse ENCODE)

To complement the human Encyclopedia of DNA Elements (ENCODE) project and to enable a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the same experimental pipelines developed for human ENCODE to annotate the mouse g

An encyclopedia of mouse DNA elements (Mouse ENCODE)

To complement the human Encyclopedia of DNA Elements (ENCODE) project and to enable a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the same experimental pipelines developed for human ENCODE to annotate the mouse g

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