Garnett H. Kelsoe

Garnett H. Kelsoe
James B. Duke Professor of Immunology
Third Year Mentor - Microbiology, Infectious Diseases and Immunology Study Program (MIDIP)
Campus mail: 117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone: (919) 613-7815

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.

Education and Training

  • Harvard University , D.Sc. 1979
  • University of Texas, Medical Branch at Galveston, Assistant Professor, Microbiology
  • University of Texas, Medical Branch at Galveston, Associate Professor, Microbiology
  • University of Maryland School of Medicine, AssociateProfessor, Microbiology & Immunology
  • University of Maryland School of Medicine, Professor, Microbiology And Immunology

Publications

Lack of B7-2 expression in the germinal centers of aged mice

The humoral immune response is known to be depressed in the aged mouse. This immunodeficiency is associated with an impairment in the formation of germinal centers, the anatomic site of antibody affinity maturation and memory B cell generation.

Mapping of antibody specificities to VH gene families.

VH gene segments represent the products of the repeated duplication and subsequent diversification of a primordial V gene element. It is widely assumed that natural selection, operating via pathogens, has played the dominant role in this process.

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