James B. Duke Professor of Immunology
Third Year Mentor - Microbiology, Infectious Diseases and Immunology Study Program (MIDIP)
Campus mail:
117 Jones Bldg, 207 Research D, Box 3010 DUMC, Durham, NC 27710
Phone:
(919) 613-7815
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.
Education and Training
- Harvard University , D.Sc. 1979
- University of Texas, Medical Branch at Galveston, Assistant Professor, Microbiology
- University of Texas, Medical Branch at Galveston, Associate Professor, Microbiology
- University of Maryland School of Medicine, AssociateProfessor, Microbiology & Immunology
- University of Maryland School of Medicine, Professor, Microbiology And Immunology
Selected Grants and Awards
- Duke CTSA (KL2)
- Duke CTSA (TL1)
- Duke Resident Physician-Scientist Program- NIAID
- Immunity to novel T/F SHIVs: variability in the co-evolution of virus and host immunity
- Complement and CR2/CD21 in the Immune Pathogenesis of HIT
- Structure-function analysis of infection- and vaccine-induced B-cell repertoires
- Basic Immunology Training Program
- Modeling affinity maturation at molecular resolution
- SHIV/HIV Env-Antibody Coevolution as a Guide to Iterative Vaccine Design
- Attenuated HSV Vaccines That Induce Protective Mucosal Antibodies
- Serial Block Face Scanning Electron Microscope
- Testing the Nearest Neighbor Approach to Active Vaccination for HIV-1
- Training Program in Inflammatory and Immunological Diseases
- Quantifying poly- and autoreactivity in therapeutic chimeric proteins
- Immunity to novel T/F SHIVs: variability in the co-evolution of virus and host immunity
- Culturing and isolating human B-cells using Athena technology
- Multiscale Systems Immunology
- Eliciting B cells to produce anti-HIV gp41 MPER-specific neutralizing antibodies
- BAFF Pathology: Novel Therapeutic Targets in Chronic Graft versus Host Disease
- T cell function in asthma depends on a novel signaling pathway
- Microsimulation of anthracis-immune system interaction