Donald Patrick McDonnell

Donald Patrick McDonnell
Chair, Department of Pharmacology & Cancer Biology
Amgen Faculty Mentor
CMB - Pharmacology and Cancer Biology
DSCB - Developmental Genetics
Third Year Mentor - Molmed - Molecular Basis of Disease Study Track
Third Year Mentor - Molmed - Regenerative Medicine Track
Third Year Mentor - Molmed - Translational Pharmacology Track
Third Year Mentor - Molmed Oncological Sciences
Campus mail: C238A Lev Sci Res Ctr, Durham, NC 27708
Phone: (919) 684-6035

The research in our group is focused on the development and application of mechanism based approaches to identify novel therapeutics for use in the treatment and prevention of hormonally responsive cancers. Specifically we are interested in the pharmaceutical exploitation of the estrogen and androgen receptors as therapeutic targets in breast and prostate cancers and in defining how these receptors influence the pathogenesis of these diseases. These efforts have led to the discovery of several drugs that are currently being evaluated in the clinic as cancer therapeutics, and to the identification of potential biomarkers and predictors of response that can help to target the use of these new drugs. Most recently we have explored approaches to treat triple negative breast cancer and have identified an important pathway that links obesity/dyslipidemia and cancer risk.

Education and Training

  • Baylor College of Medicine, Ph.D. 1988

Selected Grants and Awards

Publications

Toxicology of environmental estrogens

It has been hypothesized that environmental contaminants that modulate endocrine signaling pathways may be causally linked to adverse health effects in humans.

Pages