Christopher David Lascola

Assistant Professor of Radiology

Third Year Mentor - Neurosciences Study Program (NSS)

Campus mail: Box 3808 Med Ctr, Durham, NC 27710

Phone: (919) 684-7284

Education and Training

University of Chicago, Ph.D. 1997
University of Chicago, M.D. 1998

Selected Grants and Awards

Publications

A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.

Background -Critical limb ischemia (CLI) is a manifestation of peripheral artery disease (PAD) that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown.

Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Ascorbate (Asc) as a single agent suppressed growth of several tumor cell lines in a mouse model.

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury.

Astrocyte cytolysis by MHC class II-specific mouse T cell clones.

The brain is "immunologically privileged," in part because class I and II MHC antigens are not normally present on glia or neurons.

Astroglial acid-base dynamics in hyperglycemic and normoglycemic global ischemia

Biochemical, histological, and physiological evidence suggest strongly that astrocytes may either defend or damage brain tissue, depending on the brain carbohydrate content preceding global ischemia (28,43).

Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice.

There is emerging evidence to suggest that brain natriuretic peptide (BNP) is elevated after acute brain injury, and that it may play an adaptive role in recovery through augmentation of cerebral blood flow (CBF).

Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice.

OBJECTIVE: Gliosis refers to a range of glial cell transformations that vary according to specific brain pathologic states.

Christopher David Lascola

Education and Training

Selected Grants and Awards

Publications

A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.

Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Astrocyte cytolysis by MHC class II-specific mouse T cell clones.

Astroglial acid-base dynamics in hyperglycemic and normoglycemic global ischemia

Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice.

Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice.

CT fluoroscopy-assisted cervical transforaminal steroid injection: tips, traps, and use of contrast material.

CT-guided cervical transforaminal steroid injections: where should the needle tip be located?

Cytoskeletal actin gates a Cl- channel in neocortical astrocytes.

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Christopher David Lascola

Education and Training

Selected Grants and Awards

Publications

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