Rooney Family Associate Professor of Biomedical Engineering
Amgen Faculty Mentor
CMB - Clinical/Other
DSCB - Regenerative Medicine
Campus mail:
2353C CIEMAS, Durham, NC 27708
Phone:
(919) 613-2147
Education and Training
- Georgia Institute of Technology, B.S. 2001
- Georgia Institute of Technology, Ph.D. 2006
Selected Grants and Awards
- Mechanotransduction in Meniscus Health and Repair
- Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer
- The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Mycocardial Fuel Section
- Engineering Technologies to Determine Causal Relationships Between Chromatin Structure and Gene Regulation
- Summer Scholars Program in Genome Sciences and Medicine
- Medical Scientist Training Program
- University Training Program in Biomolecular and Tissue Engineering
- Deciphering the regulation of gene expression in the etiology of LOAD
- Postdoctoral Training in Genomic Medicine Research
- Training Program in Developmental and Stem Cell Biology
- To support research on the development of CRISPR-based epigenome editing tools to refine genome wide association studies
- Evolving High Potency AAV Vectors for Neuromuscular Genome Editing
- Regulatory Mechanisms of CD4+ T Cell Differentiation
- Bioinformatics and Computational Biology Training Program
- In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice
- CRISPR/Cas9-Based Gene Editing for the Correction of Duchenne Muscular Dystrophy
- Designing a next generation vector for CRISPR/Cas9-mediated gene editing to treat Duchenne muscular dystrophy
- Genome Editing For Duchenne Muscular Dystrophy
- Epigenome Editing Technologies to Control Diverse Biological Functions
- Functional characterization of regulatory variants associated with maternal hyperglycemia
- Collaborative Research: Adapting Cas9 Protein from CRISPR as a Structural Unit for Molecular Assembly
- Non-viral delivery of CRISPR/Cas9 for targeted gene replacement
- REU Site for Meeting the Grand Challenges in Engineering
- Developing Brain-penetrant G9a/GLP Inhibitors for Treating Prader-Willi Syndrome
- Enhancing Neuronal Reprogramming with Epigenome Editing
- Enhancing Neuronal Reprogramming with Epigenome Editing
- Investigating Autophagy in GSD-Ia
- Development of AAV-Based Curative Therapies for Correcting Duchenne Muscular Dystrophy by Targeted Genomic Integration
- Treating Duchenne Cardiomyopathy in the Mouse Model by Gene Repair
- Combinatorial Biomimetic Systems for High-Throughput Manipulation of Genome-Edited Dystrophic Muscle Stem Cells
- Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease
- Novel Approaches for Correcting Respiratory Insufficiency in Pompe Disease
- Reprogrammed autologous T cells to promote transplant tolerance
- Systemic EGFRvIII-targeted bispecific antibody as immunotherapy for glioblastoma
- Defining the Mechanisms of Gene Regulation and Drug Resistance in Cancer
- Decoding and Reprogramming the Corticosteroid Transcriptional Regulatory Network
- Trans-regulatory mechanisms of glucocorticoid-mediated transcriptional repression
- Genome engineering for Duchenne muscular dystrophy
- Engineering Novel Genome Engineering Systems
- Circulatory system and integrated muscle tissue for drug and tissue toxicity
- Engineering Targeted Epigenetic Modifiers for Precise Control of Gene Regulation
- A Platform Technology for High-Throughput Screening of Gene Regulatory Elements
- Functional Tissue Engineering of Cartilage Using Induced Pluripotent Stem Cells
- MD140071 Multiplex CRISPR/Cas9-Based Genome Engineering for the Genetic Correction of Duchenne Muscular Dystrophy
- CRISPR/Cas9-based genome editing in mouse models of Duchenne muscular dystrophy
- Scaffold-Mediated Gene Delivery for Engineering of Osteochondral Tissues
- Gertude B. Elion Mentored Medical Research Award
- Genome Editing of Stem Cells for Analysis of Osteoarthritis Causal Variants
- CAREER: Photoregulated Gene Expression for Spatiotemporal Control of Morphogenesis
- Engineering Morphogenetic Factors for Enhanced Genetic Reprogramming
- Engineering New Biological Therapies for Arthritis
- Live-Animal Micro-CT System
- Spatially Controlled Gene Delivery of Morphogenetic Factors from Woven Scaffolds