
Analytic Interests.
1) Issues in the Design of Medical Experiments: I explore the use of reliability/generalizability models in experimental design. In addition to incorporation of reliability, I study powering longitudinal trials with multiple outcomes and substantial missing data using Mixed models.
2) Issues in the Analysis of Repeated Measures Designs & Longitudinal Data: Use of Hierarchical Linear Models (HLM) or Mixed Models in modeling trajectories of multiple variables over time (e.g., physical and cognitive functioning and Blood Pressure). My current work involves methodologies in simultaneous estimation of trajectories for multiple variables within and between domains, modeling co-occuring change.
Areas of Substantive interest: (1) Experimental design and analysis in gerontology and geriatrics, and psychiatry,
(2) Multivariate repeated measures designs,
Education and Training
- Columbia University, DrPH 1990
Selected Grants and Awards
- Epigenetic Mechanisms Promoting Longevity
- Duke CTSA (KL2)
- Duke CTSA (TL1)
- Metabolomic & Radiographic Markers of Fracture Risk Among Older Adults with Diabetes
- Addressing Barriers to Adult Hearing Healthcare
- Behavioral and Physiology in Aging
- IPA-Carl Pieper
- Sustained blood pressure control and progression of multimorbidity
- Point of Care Testing to Improve Monitoring of LVAD Patients
- Biomarkers of Caloric Restriction in Humans: the CALERIE Biorepository
- Mentoring Intervention Development in Fall and Fracture Prevention
- IPA - Richard Sloane - Pieper
- PCORI
- An Enhanced Protein Weight Loss Intervention
- Altitude Study
- A point-of-care, biomarker-based test to predict non-healing in chronic wounds
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative
- Does Meal-based Enhancement of Protein Intake Augment Long-term Responses to Sarcopenic Obesity Reduction?
- Pioneering Health Information Technology (R00)
- Does Beef Protein Preserve Muscle Mass and Function During Weight Loss in Frail, Obese Older Adults?: A Follow-Up Study
- Exercise, Nitric Oxide Bioavailability and Arteriovenous Fistula Maturation
- Improving Quality of Life Measurement in Older Dialysis Patients
- Adherence to Venous Thromboembolism Prophylaxis Guidelines in Hospitalized Elders
- Assessment of Physical Performance, Walking Mechanics, and the Cost-effectiveness of Revision Total Ankle Replacement
- Multisite RCT Investigating the Efficacy of Massage in Osteoarthritis
- Measuring and Talking to Patients about the Accuracy of Data used in Patient Outcomes Research
- A High-Protein Weight Loss Treatment for Sarcopenic Obesity
- Clinico-Genomic Assessment of Performance Status in Elderly AML Patients
- Behavior And Physiology In Aging
- Disentangling Late Life Depression, Vascular Lesions and Functional Decline
- Pioneering Health Information Quality (K99)
- Eating Disorders in Type 1 Diabetes: Mechanisms of Comorbidity
- Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD
- CALERIE
- CALERIE Non-competing Extension with Funds
- IPA-Richard Lawrence Whitley
- IPA - Richard Sloane
- Developing Interventions to Improve Function in Seniors with Comorbid Conditions
- Cognitive Endophenotypes for Genetic Studies of Alzheimer's Disease
- Curriculum Development Centers
- Subtypes and Trajectories of Depression in Older Adults
- IPA - Richard Sloane
- IPA - Carl Pieper
- Epidemiology of Dementia in Cache County, Utah (Bridge-Funding Request)
- Epidemiology of dementia in Cache County, Utah
- Caffeine and Glucose Regulation
- Mindfulness Based Weight Loss Maintenance
- Adapting Marital Therapy in Older Adults with Depression
- CALERIE
- IPA - Carl Pieper
- Depression and Physical Functioning in Older Adults
- IPA - Carl Pieper
- Walking Activity and the Burden of Multiple Morbidities
- Insulin Resistance and Polycystic Ovary Syndrome
- Surveillance And Analysis Of The UNC Alumni Heart Study
- Herpes Zoster and Medications in the Elderly
- Treatment Outcomes of Vascular Depression
- Meditation for High Blood Pressure
- Antidepressant Use by Older Adults
- Disability In Nursing Home Residents With Dementia
- Living Arrangements and Health Status in Late Life
- Caffeine Effects On Stress Reactivity
- Geriatric Depression: Risk Factors For Adverse Outcomes
- Race Differences in Prevalence and Incidence of Dementia
- Impact of geriatric care on drug related problems
- Phase Ten Year Followup
- Study Of Depression
- Phse Ten Year Follow-Up
- Crc/Pe For The Study Of Depression
- Geratric Depression: Risk Factors For Adverse Outcome
- Claude D Pepper Older Americans Independence Center
- Surveillance And Analysis Of The Unc Alumni Heart Study
- Suboptimal Drug Use And Health Outcomes In The Elderly
- Caffeine Effects On Stress Reactivity
- Caffine Effects On Stress Reactivity
- Depression In Elderly Cardiac Patients
- Cognitive Impairment And Medication Appropriateness
- Osteoporosis And Disability In Life Care Community Women
- Claude D. Pepper Older Americans Independence Center
- Claude D. Pepper Older American Independence Centers
- Neuroimaging Of Age Related Cognitive Changes
- Osteoporosis And Disability In A Life Care Community
- Osteoporosis And Disability In Life-Care Community Women
- Research Support Services For Gerontology Center
- Renewal Of Established Populations For Epidemiologic Studi