Anna Mae Diehl

Anna Mae Diehl
Florence McAlister Professor of Medicine, in the School of Medicine
Office of Physician-Scientist Development
Third Year Mentor - Anesthesiology, Surgery, and Environmental Physiology Study Program (ASEP)
Campus mail: Duke Box 3256, 905 S. Lasalle Street, GSRB 1, Durham, NC 27710
Phone: (919) 684-2366

Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD).

Research by our group has advanced understanding in two main areas: 1) immune system regulation of liver injury and regeneration and 2)the role of fetal morphogens, such as the hedgehog pathway, in regulating fibrotic responses to liver damage. Our basic research programs have been enjoyed continuous NIH support since 1989. We welcome students, post-doctoral fellows and visiting scientists who have interests in this research area to contact us about training opportunities and potential collaborations.

Since 2001 we have also been an active participant in the NIDDK-funded Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), a national consortium comprised of 8 university medical centers selected to generate a national registry for patients with NAFLD and to conduct multicenter treatment trials for this disorder. We are actively recruiting patients for this program, as well as a number of other industry-supported NAFLD studies.

Education and Training

  • Georgetown University, M.D. 1978
  • Johns Hopkins University, Medical Resident, Medicine
  • Johns Hopkins University, Fellow in Gastroenterology, Medicine

Selected Grants and Awards


Alcoholic liver disease

Liver injury may develop in some people who consume alcohol. The pathogenesis of liver damage in such subjects remains obscure. Major histopathologic features of alcohol-associated liver injury include steatosis, steatonecrosis, and cirrhosis.

Alcoholic liver disease.

Alcohol has been implicated in the genesis of liver disease for centuries. Significant progress has been made in our understanding of the pathogenesis of ALD.

Alcoholic liver disease: Natural history

Alcohol has been implicated in the genesis of liver disease for centuries. Modern epidemiological data from many societies corroborate the correlation between per capita consumption of alcohol and deaths from cirrhosis.