Cell type classification and circuit mapping in the mouse brain

May 4, 2021 - 12:00pm to 1:00pm
Hongkui Zeng, hosted by Eva Naumann

Duke Neurobiology welcomes Hongkui Zeng, PhD, Executive Director of Structured Science at the Allen Institute for Brain Science in Seattle. For connection info to her Zoom seminar "Cell type classification and circuit mapping in the mouse brain", email d.shipman@duke.edu.
Abstract: To understand the function of the brain and how its dysfunction leads to brain diseases, it is essential to have a deep understanding of the cell type composition of the brain, how the cell types are connected with each other and what their roles are in circuit function. At the Allen Institute, we have built multiple platforms, including single-cell transcriptomics, spatial transcriptomics, single and multi-patching electrophysiology, 3D reconstruction of neuronal morphology, and high throughput brain-wide connectivity mapping, to characterize the transcriptomic, physiological, morphological, and connectional properties of different types of neurons in a standardized manner, towards a multi-modal taxonomy of cell types and a description of their wiring diagram for the mouse brain, with a primary focus on the cortex. Building such knowledge base lays the foundation for decoding the computational mechanisms of circuit function.